cardiology question

[IM05]

Here is the question.


VPC ( ventricular premature beats ) and Atrial premature beats are very common even in the very healthy young individuals
( ~ 50- 60 % ) and doesn't require medical attention unless they are too frequent- we discussed this in a previous thread. Is it true that these are higher in prevelance in hyperadrenergic
( or less parasympathetic ) status ??

I was under the impression that overall all the tachyarrhythmias are more common during symathetic activation but could it be the local cardiac cells that are more easily stimulated because of local injury (Eg : post MI etc) and the result of this is tachycardia which appears like a sympathetic response.


will appreciate your views on this.

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[Kalel]

Yup, conditions associated with hyperadrenergic conditions (the extreme would be a pheo, but others include MI's in which increased levels of epi is thought to play a role in maladaptive remodeling and increasing cardiac muscle demand) are associated with ventricular arrhythmias such as PVC's or VPC's. Here are some articles and abstracts that I was able to find on the subject:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9752614
http://www.ncbi.nlm.nih.gov/entrez/...ve&db=pubmed&dopt=Abstract&list_uids=10331168
http://www.emedicine.com/med/topic1816.htm

 

[IM05]

Thanks for your response, I am still a bit confused about the pathophysiology, couldn't get those 2 articles anywhere one being written in Japanese, the other journal title is not found in a couple of good places.

anyhow, could someone comment on this hypothesis: obesity is assosiated with sympathetic activation ( I read somewhere they measured Adrenaline/ Noradrenaline levels ) and if we all believe PVC is more common with hyperadrenergic states then do obese subjects have a higher incidence of PVC and all tachyarrhythmias ??