CD4 vs CD8

[DingDongD]

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Hi there,

I am having some difficulty understanding immunology concepts. So, if there is an obligate intracellular bacteria like chlamydia, is it killed by CD4 or CD8 predominantly? I would think CD8, but I am not too sure. The reason I am asking this question is TB seems to be mostly killed through a CD4 response even though it is an intracellular organism. Thanks so much!

 

[wanderingorion]

Antigen-specific CD8(+) T cells and protective immunity to tuberculosis. - PubMed - NCBI