Chads video question: esters-->amide directly?

[jiejsun]

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So in Chads video on carboxylic acid derivatives, Chad noted that ester can be transformed to amide with R2NH, acid catalyzed. But from what I learned and also from Kaplans review notes, amides can be formed only by acid chlorides + amines, or acid anhydrides + ammonia. Thus esters need to be turned into carboxylic acids before forming amide.

Can ester go to amide directly then?

 

[asdfray]

ester can directly be converted to amide with catalyst.

draw out the mechanism and try to understand why that it is.
also, amides can also be made using acid chloride and anhydrides.

 

[HAWKDDS2014]

Yes, you can make an Amide from an Acid Chloride. You can make any acid derivative as long as the product is less reactive than the starting material. For example you can go from acid chloride to amide, anhydride, ester. But you can't go from an amide to an acid chloride directly.