Nov 30, 2011
50
0
MA
Status
Pre-Dental
So in Chads video on carboxylic acid derivatives, Chad noted that ester can be transformed to amide with R2NH, acid catalyzed. But from what I learned and also from Kaplans review notes, amides can be formed only by acid chlorides + amines, or acid anhydrides + ammonia. Thus esters need to be turned into carboxylic acids before forming amide.

Can ester go to amide directly then?
 

asdfray

currently at work
Apr 28, 2010
465
3
Status
Dental Student
ester can directly be converted to amide with catalyst.

draw out the mechanism and try to understand why that it is.
also, amides can also be made using acid chloride and anhydrides.
 
Nov 25, 2010
33
0
Status
Pre-Dental
Yes, you can make an Amide from an Acid Chloride. You can make any acid derivative as long as the product is less reactive than the starting material. For example you can go from acid chloride to amide, anhydride, ester. But you can't go from an amide to an acid chloride directly.