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Chromosomal Translocations

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Thoroughbred_Med

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After a chromosomal translocation occurs, how do these new derivative chromosomes know how to line up at metaphase?

After a translocation happens to a chromosome it isn't the same anymore and so how does it know how to find its homologous partner?

My hunch is that the centromere has recognition abilities but I'm not to sure...


Can anybody help me understand this? thanks!
 

Nugester

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You are partially correct. The homologous sequence will pair up. Any non-homologous sequence resulting from the translocation sticks out/bends and pairs with another homologous sequence. Then what the daughter cells get depends on alternate/adjacent 1/2 segregation, which leads to balanced or unbalanced gametes (viable/non-viable cells). Here is a easy picture:

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