classical C3 convertase? BRS conflicts with parham

[Ramoray]

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just wondering if anyone happens to be reviewing immno, probably not an important thing to know but just happened to notice in the micro/immono BRS they say that C4bC2a is the classical c3 convertase but in my immuno class and the only immuno book i have, which is Parhams, that it is C4bC2b which makes more sense but anyone know which is right?

 

[BrooklynDO]

just wondering if anyone happens to be reviewing immno, probably not an important thing to know but just happened to notice in the micro/immono BRS they say that C4bC2a is the classical c3 convertase but in my immuno class and the only immuno book i have, which is Parhams, that it is C4bC2b which makes more sense but anyone know which is right?

as far as i am aware the "a" ' s leave, being anaphylactic, and the right c3 convertace is C4bC2b

 

[Resident Alien]

C4b2b is being used in newer text books now. C4b2a is technically correct (long story about how what they thought was 2a ended up being 2b etc)

 

[Idiopathic]

My immuno prof told us that this point is still being debated among immunologists...no sense in worrying about it.

 

[bella_dottoressa]

My immuno prof told us that this point is still being debated among immunologists...no sense in worrying about it.

yeah really, ya nerd. maybe try getting a life and stop looking for inconsistencies in your immunology texts. isnt this the kid who wanted to study step 1 a year early?

( 😉 😉 😉 😉 )

 

[Idiopathic]

yeah really, ya nerd. maybe try getting a life and stop looking for inconsistencies in your immunology texts. isnt this the kid who wanted to study step 1 a year early?

( 😉 😉 😉 😉 )

True...I just actually made a marking in my immuno notes about exactly this thing (he had us cross it out) and just happened to review immuno three nites ago (so there) 😛

 

[bella_dottoressa]

aww, my comments were directed at the OP not you! 🙂

 

[elias514]

C4b2a is the classical C3 convertase, even though the 2a component violates the rule that "a" components (e.g., C3a) drift away while "b" components adsorb to the surface of a foreign microbe. The C2 protein is the one exception to this rule...you just have to memorize this fact. Thus, C4b2a is correct, at least traditionally so (and scientists strongly resist change).

BTW I was a microbiology major in college, so that's how I know this stuff--I had to take a lot of immunology.