Clindamycin vs. Chlorophenicol MOA

[acciddropping]

Can you explain how examiners like to ask the MOA for Clindamycin and Chlorophenicol? To me, it sounds the same based off the FA explanation - Thanks.

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[Apoplexy__]

?

Do you have FA 2014? pg. 183 has a nice picture differentiating them.

Clindamycin = Translocation
Chloramphenicol = Peptidyl transferase

I think the only way I've ever had these asked to me is "What does drug X do? Answer = mechanism Y". I don't think I've ever had to compare/contrast them.

 

[acciddropping]

?

Do you have FA 2014? pg. 183 has a nice picture differentiating them.

Clindamycin = Translocation
Chloramphenicol = Peptidyl transferase

I think the only way I've ever had these asked to me is "What does drug X do? Answer = mechanism Y". I don't think I've ever had to compare/contrast them.

I have 2013 but it also has a picture. What confuses me is that Macrolides also inhibit Translocation (but it involves 23s rRNA of 50s ribosome). MOA for Chloramphenicol and Clindamycin are below - I am not sure if Transpeptidation is different than Blocking peptidyltransferase.

 

[thehundredthone]

Looks like the error from 2012 carried over into 2013. Clindamycin blocks translocation, not transpeptidation. Have you checked the errata for your edition?

 

[acciddropping]

Looks like the error from 2012 carried over into 2013. Clindamycin blocks translocation, not transpeptidation. Have you checked the errata for your edition?

Thanks for pointing that out and I just checked - it's an error. Clindamycin blocks translocation.

 

[thehundredthone]

Before I started reading FA I sat down and made all the corrections from the errata. Some errata get revised, some even get reversed, so stay abreast of all the changes. It's a good idea especially with a book like FA that's infamous for these errors.

 

[acciddropping]

Before I started reading FA I sat down and made all the corrections from the errata. Some errata get revised, some even get reversed, so stay abreast of all the changes. It's a good idea especially with a book like FA that's infamous for these errors.

I went ahead and printed out 10 pages of errata - I should have done that before! thanks.

Do you know the difference between Macrolide and Clindamycin for the difference in MOA - they both block translocation. Macrolide is at 23s rRNA of the 50s and Clindamycin at 50s. I mean how do I know what to choose?

 

[Enzymes]

I went ahead and printed out 10 pages of errata - I should have done that before! thanks.

Do you know the difference between Macrolide and Clindamycin for the difference in MOA - they both block translocation. Macrolide is at 23s rRNA of the 50s and Clindamycin at 50s. I mean how do I know what to choose?

USMLE is much more likely to test differences in other ways (like which drugs are used for which organisms, what are the main side effects). If you know the one line mechanism for each drug, you will be fine. Don't stress on the minutia of distinguishing between clindamycin and macrolide mechanisms.