Maybe AAFP articles?
Ditto what
@Doctor4Life1769 said, but as he mentioned "activating" medications, one of the biggest mistakes I see in psych med Rx'ing is not doing a very pointed and thorough screen for bipolar tendencies. Family history for psych really counts for something, so I wouldn't skim over that part of history like I might for other complaints. Up to 1-3/10 patients presenting to primary care clinic for depression have bipolar disorder depending what study you read. Remember only 1 lifetime episode of hypomania/mania can garner the diagnosis of BPD 1 or 2 (or at least should make you wary), and even if episode is 2/2 medication in a patient, I would be very cautious and go low and slow w/ close follow up in those patients. Hypomania can also resemble ADHD and anxiety. Mixed episode, dyphoric mania or dysphoric hypomania, could all present looking like depression/anxiety/ADHD in whatever permutation you like. Please take the time to really consider BPD.
If suspicion is strong for BPD, I personally would not start those patients on any SSRI/SNRIs or other uppers. Some FPs will start mood stabilizing anticonvulsants (and not show enough respect to lamotrigine and SJS) or start antipsychotics themselves (check Qtc first for certain ones, others don't need it actually) and I don't know what to say about that, but *I* wouldn't ever start an SSRI/SNRI alone in a patient I thought might have BPD. Anything but mood stabilizers in BPD, certainly unopposed other classes of med, should go to psych if you ask me. You can justify starting some treatment of BPD while waiting to get in to psych probably, but sending home a BPD 1 OR 2 patient home with the other stuff is asking for trouble. Contrary to some beliefs I've heard, Celexa or Lexapro alone in BPD can also be a disaster.
It's also relevant for your "ADHD" cases to do a thorough BPD screen before handing out any "uppers".
Bipolar is just not something you want to miss when you Rx psych drugs, you can really **** some people up.
If you ever dabble in antipsychotic rx'ing, definitely be aware of not only s/s of TD but Parkinsonian sx, extrapyramidal sx. It's embarassing when people don't recognize difficulty swallowing, muscle spasm/stiffness/twitching (dystonia), "restless legs" or psychomotor agitation (akithisia), fatigue (bradykinesia) or constipation as medication SE. EPS sx predict a higher risk of TD while we're at it. Antipsychotics also mask TD sx, so more reason to beware EPS sx.
I don't know about varencicline but know that buproprion lowers the seizure threshold, and contraindicated in anorexic/bulimic/eating disorder not only for that reason but also suppresses appetite, so those folks often try to angle for that med, and also some of your ADHD meds too for weight loss.
A lot of patients don't know they need to knock off the weed for their depression/fatigue. Also consider hx of family psychotic illness and risk in pot-smokers or med MJ prescribing.
Patients don't often report hearing voices unless asked, that can be a sign of psychotic depression OR BPD, or even just run of the mill alcoholism. Isolated auditory hallucinations years after recovery from heavy alcoholism is possible.
So-called "rebound" anxiety in ex-heavy drinkers up to years after quitting is possible too.
As far as ADHD/depression, screen for sleep apnea or other sleep disorders too. Too many people forget about sleep hygeine, melatonin as options. Part of sleep hygeine can include sunrise simulators.
Blue light therapy not only for SAD but can also work for depression in general. Still use with care in those you might suspect bipolar but less likely to induce severe mania with light than meds, so it's a safer way to approach initial treatment of mild depression IMHO.
Another lifestyle issue is caffeine w/in 8 hrs of bedtime (has long half life). I know people that guzzle a whole pot before bed w/ no problems, and "ADHD" or "depression" I've cured just by having folks cut back on caffeine, or stop drinking it after 2-4 pm. People forget about soda in that equation too.
The latest psych research I read, and I think I saw an AAFP article on anxiety, supported that benzos are still first line and more effective for GAD than any of the other SSRIs in adults. Granted, I think most providers shy away from benzos and reach for SSRIs for anxiety for other reasons, and leave benzos for last or to the psychs, and I get it, I do. Just throwing the info out there.
Also, that social anxiety can be mistaken for GAD and vice versa, phobias and OCD, and while GAD and OCD can respond well to meds, they are less useful in social anxiety/phobias where therapy has the advantage over meds. For OCD/GAD med and therapy together are more effective than either alone, as with major depression.
Just my 2 cents on psych stuff I see missed/may be relevant to primary care considerations.
As far as resources, I know there's online stuff that makes picking out a starting meds for major depression, GAD, mild OCD, ADHD, taking into account SE effect profiles for the individual patient and age, fairly easy, but the key is proper diagnosis to begin with and appropriate lifestyle modifications (eg fatigue from caffeine and sleep apnea leading to depression is not likely to benefit much from SSRI)
I'd have to google to find these guides, but I hope this helps somewhat.
