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foofighter7

Member
10+ Year Member
Jun 2, 2005
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How exactly does this work to help treat infertility in PCOS?

I don't get how it says its an estrogen agonist BUT will prevent inhibition of LH/FSH

Thanks!
 

Ty Webb

I like you Betty...
10+ Year Member
5+ Year Member
Mar 9, 2008
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Medical Student
It's an antagonist at the hypothalamus. Therefore less estrogen binding at hypothalamus --> inc. GnRH --> inc. LH + FSH
 

DoctwoB

10+ Year Member
Jan 10, 2010
1,834
1,173
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Attending Physician
How exactly does this work to help treat infertility in PCOS?

I don't get how it says its an estrogen agonist BUT will prevent inhibition of LH/FSH

Thanks!
Clomifene is a partial estrogen receptor agonist, which means, in the presence of estrogen at the hypothalamus, it acts as an antagonist.
 
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