Step I Clomifene

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foofighter7

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How exactly does this work to help treat infertility in PCOS?

I don't get how it says its an estrogen agonist BUT will prevent inhibition of LH/FSH

Thanks!
 
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It's an antagonist at the hypothalamus. Therefore less estrogen binding at hypothalamus --> inc. GnRH --> inc. LH + FSH
 
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foofighter7 said:
How exactly does this work to help treat infertility in PCOS?

I don't get how it says its an estrogen agonist BUT will prevent inhibition of LH/FSH

Thanks!
Click to expand...

Clomifene is a partial estrogen receptor agonist, which means, in the presence of estrogen at the hypothalamus, it acts as an antagonist.
 
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