Is there any rational reason to use the combination of clonidine and clonazepam for any indication? That is without any other antihypertensive and antiseizure medication. One of the first weird things I learned working retail in downtown was the abuse potential of these two agents. It's always fishy seeing "Clonidine 0.3mg po tid #90" and "Klonopin 2mg po tid #90". My pharmacist never fills these scripts, but I have seen it dispensed at my suburban community rotation sites.