Since starting med school I have reverted to "lurker mode", but out of appreciation for the people who posted their experiences, I will post mine. I found it really helpful to read these as my "D-day" approached.
Took the beast yesterday. Not quite sure what to think; most of my classmates have been saying that it was virtually impossible: all 2nd and 3rd level reasoning, super-picky details that smacked of PhD material, and very few that they we sure that they answered correctly. I, on the other hand, am afraid that I got an easy form and will get screwed because of it. Yes, there were some questions I didn't know, but a whole lot were so easy and straightforward I stared at the screen and was like "Are you kidding me?" Examples: What is elevated in the sweat test? What ion is not transported properly in CF? What virus causes mono? What autonomic receptor is blocked in drugs used to treat hypertension and BPH? Now I am worried, mainly because everyone says that if you leave thinking you barely passed you did awesome, and if you think you did fine you barely passed.

I thought it was a lot like the path mini-board in terms of difficulty: hard questions were the ones where you had to think a bit and weren't quite sure the answer you put down was right but oh well.
Block difficulties: #'s 1-4 seemed like an even spread, #5 was pretty easy, and #'s 6 and 7 left me feeling haggard and a tad depressed. And I don't think it was because I was getting tired- my school made us take a Kaplan full-length test, and my scores actually went up at the end on that.
Themes: ENDOCRINE, BEHAVIORAL SCIENCE, NEURO, RECEPTORS. Endocrine is just confusing to me no matter how hard I study, so I think the questions were on par with the path & phys mini-boards. Repro & DM seemed to dominate. I thought Kaplan's behavioral questions were pretty convoluted; knowing FA was sufficient. Neuro was also straightforward provided that you understood it to begin with, and mostly anatomy-based. I had a decent understanding of HY Neuro, and felt that most of my neuro questions were slam-dunks. With regard to receptors, I doubt I had a ton of those questions, but go more than enough of them to inwardly groan every time a receptor question came around, which was at least 1-2 per block. I even had a hideous (and confusing) "up down" question of a whole smattering of receptors! (You know, the ones with all the arrows). I don't think HY Molecular really helped all that much; to say the least, know ANY and every receptor possible or be really comfortable making educated guesses.
Biochem was very straightforward IF you put in the time to memorize the main enzymes involved. I had about 5-7 questions on B12 related to alcoholics.
Very little: immuno, devo
For pharm, the overwhelming majority of questions involved SIDE EFFECTS. Very little MOAs, mechanisms, etc. Know your stinking side effects!
Path: I listened to Goljan, bought the Rapid Review for Path, and read through most of his High Yields. (Like everyone says, he's the man.) Maybe that's why I thought the test wasn't that bad? Sadly, only time will tell. I am freaking out now because everyone I know said it was SO hard, and I thought it was doable.
NOTE: Did not pay any money to take the NBME samples. Just couldn't bring myself to do it. I remember reading someone saying that if you know FA really well, answers will seem to jump out at you; I agree. And for those of you who are slow test takers: most questions at the end of a paragraph could have stood alone or are unrelated, and a good number of lab values provided in the stems aren't necessary. Skim the stem, read the question, then go back up if you must. Because time will be short, especially if you like to go back over your work before closing out a block.
So that's it. Time will tell.
**********update!!***********
Score: 252/99
I'm over the moon, to say the least.
😀
****************************
Kaplan Q-bank: final percent was unreliable, since I used it more as a learning tool and less as a testing/assessment tool. I took a few mixed tests towards the end, and was getting 75-85%, but once you've taken enough Q-bank you tend to see questions on the same information, so... yeah.
Books used: Goljan Path Rapid Review, HY Neuro, FA 2004, FA 2006 (used 2004 to review a subject at once, 2006 to review organ systems); and (gasp!) no, I didn't get through all of FA- most of it, especially the biggies, but certainly not all of it. Advice: if you're anything like me... unless you plan your studying out to a tee and give yourself over a week extra for slip-ups, time will get short and things will have to get tossed aside.