5+ Year Member
- Aug 23, 2014
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Would expect study to be most rigorous possible under the circumstances. This is john ioannidis’ group.
“Ioannidis's 2005 paper "Why Most Published Research Findings Are False" is the most downloaded paper in the Public Library of Science and is considered foundational to the field of metascience. In the paper, Ioannidis demonstrates that most...”
Right because the patient had lupus and was Using the medication. Not sure how the hypofrac plays into it.
The frequentist approach is the most conservative and no assumptions about priors are made. Most clinical trials use this approach and as a result are conservative. Bayesian approaches invoke pre-test probabilities and are more efficient. CTEP tends to be conservative. My point is not to use this paper to bash all of science. A well-designed, randomized controlled trial is the best method to determine the true effect.