Difference Between Avinza & Kadian

[josh6718]

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Does anyone know what the difference between the two is?

Equally confusing is that they are both available in ER 60 mg capsules, yet I did not think the two brands were AB rated?

 

[TLAD123]

Does anyone know what the difference between the two is?

Equally confusing is that they are both available in ER 60 mg capsules, yet I did not think the two brands were AB rated?

Avinza was originally developed for once daily dosing. Kadian for twice daily.

Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3004644/

 

[All4MyDaughter]

Brands are never AB rated to each other.

 

[npage148]

Brands are never AB rated to each other.

That sounds like a challenge

 

[KidPharmD]

To be more specific RLD's are never AB rated to each other. Usually we can use the term "Brand" and "RLD" interchangeably, however, the idea of "Branded Generics" means that sometimes a "Brand" is not a RLD.

Avinza and Kadian are both RLD's. The release profiles are not the same. Whether they actually turned out to be clinically different is debatable.