Digoxin: lowers heart rate, but decrease action potential. How?

This forum made possible through the generous support of SDN members, donors, and sponsors. Thank you.

whatdidigetinto

Membership Revoked
Removed
10+ Year Member
Joined
Aug 13, 2012
Messages
212
Reaction score
3
Sent from my Motorola Nexus X using SDN Mobile

Members don't see this ad.
 
Thats because Dig has 2 MOA:

1) Blocks Na/K channels>decreases Na/Ca exhange >more Ca inside the cell> increased contractility. (positive inotropy)
2) Reduces heart rate by via vagal nerve stimulation>M2 receptors>decrease AV nodal conduction(negative chronotropy)

An interesting note is that in overdose: Patients complain of diarrhea, nausea,.etc. Why? Due to blockade of Na/K channels elsewhere in the body (including the gut, nerves).
 
Top