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Can anyone tell me if these points about DCM have any errors?
(wrote by me; I'm trying to organize this in a memorizable way)
Pathogenesis of DCM:
(wrote by me; I'm trying to organize this in a memorizable way)
Pathogenesis of DCM:
- Decrease in myocardial contractility
- Chronic alcoholism (alcohol + metabolites are toxic to myocardium)
- Myocarditis (damages myocardiocytes)
- Coxsackie B virus
- Trypanosoma cruzi
- Doxorubicin, daunorubicin
- Chronic cocaine use
- Peripartum cardiomyopathy
- The decrease in myocardial contractility results in progressive cardiac dilation, because blood is always left over after systole, which increases preload, etc.
- The progressive cardiac dilation further decreases systolic performance as the sarcomeres are stretched past L0.
- The volume overload is compensated by eccentric hypertrophy, but since it doesn't increase myocardial thickness (like concentric hypertrophy does), it doesn't really help the systolic dysfunction.
- Systolic dysfunction is manifested by decreased ejection fraction.
- Eventual biventricular congestive heart failure, resulting in pulmonary (LV) and systemic (RV) congestion.
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