Dilated cardiomyopathy

[Ven0m]

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Can anyone tell me if these points about DCM have any errors?
(wrote by me; I'm trying to organize this in a memorizable way)

Pathogenesis of DCM:

1. Decrease in myocardial contractility
   1. Chronic alcoholism (alcohol + metabolites are toxic to myocardium)
   2. Myocarditis (damages myocardiocytes)
      1. Coxsackie B virus
      2. Trypanosoma cruzi
   3. Doxorubicin, daunorubicin
   4. Chronic cocaine use
   5. Peripartum cardiomyopathy
2. The decrease in myocardial contractility results in progressive cardiac dilation, because blood is always left over after systole, which increases preload, etc.
3. The progressive cardiac dilation further decreases systolic performance as the sarcomeres are stretched past L0.
4. The volume overload is compensated by eccentric hypertrophy, but since it doesn't increase myocardial thickness (like concentric hypertrophy does), it doesn't really help the systolic dysfunction.
   1. Systolic dysfunction is manifested by decreased ejection fraction.
5. Eventual biventricular congestive heart failure, resulting in pulmonary (LV) and systemic (RV) congestion.

 

[theNDhopeful44]

Looks good to me. Remember that T. cruzi --------> Chagas disease

 

[Ven0m]

Looks good to me. Remember that T. cruzi --------> Chagas disease

Thanks man. Cruzin in my benz

 

[placeboconspiracy]

Thanks man. Cruzin in my benz

And Park my Benz for Benztropine in Parkinson's!