I did a bit of a search
I found a couple of things from NASA...
Ballard RE, M Wilson, DE Watenpaugh, AR Hargens, LM Shuer, J Cantrell, and WT Yost. Noninvasive measurement of intracranial volume and pressure using ultrasound. American Institute of Aeronautics and Astronautics Life Sciences and Space Medicine Conference, Book of Abstracts, pp. 76-77, Houston, TX, 3-6 March 1996.
Space motion sickness and headaches are a significant problem among astronauts during spaceflight. Seventy-three percent of Shuttle astronauts exhibit symptoms of space motion sickness (Jennings et al., 1993), which may persist through the first three days of flight and have an adverse effect on crew performance and mission progress. Although the etiology of space motion sickness still remains unclear, the symptoms may result, in part, from alterations of intracranial circulation and pressure. In a Joint NASA/NIH Workshop on Research in the Microgravity Environment (20-21 January 1994), intracranial pressure (ICP) was identified as one of the most important parameters to investigate for problems of astronauts in space and for several diseases of patients on Earth. However, current techniques for monitoring ICP are invasive and thus impractical for use in space.
On Earth, abnormally-elevated ICP occurs in 50-75% of patients with severe head trauma (Miller et al., 1992). In cases where ICP increases to values above 20 mmHg, a 95% mortality rate has been observed. Secondary brain injury due to head trauma can therefore be greatly reduced by the prompt detection and treatment of elevated ICP. A noninvasive technique for monitoring ICP would aid not only the initial assessment of increasing ICP, but could also monitor the efficacy of treatment over an extended period of time without the high risk of infection and cost associated with invasive techniques.
Although the skull is often assumed to be a rigid container with a constant volume, sensitive measurements indicate that the skull expands with increases in ICP (Heisey and Adams; 1993, Heifetz and Weiss, 1981). Recent work in our laboratory has investigated the use of ultrasound to measure non-invasively these slight changes in intracranial volume that occur with changes in ICP. A new instrument based on a pulsed phase-lock loop concept has been developed to measure the ultrasonic phase velocity accurately in condensed matter (Yost and Cantrell, 1992). The instrument transmits a 500kHz ultrasonic tone burst through the cranium via a transducer placed on the head. The ultrasonic wave passes through the cranial cavity, reflects off the inner surface of the opposite side of the skull, and is received by the same transducer. The device then uses a phase comparison technique to quantify distance across the skull. Sensitivity of this method for measurement of intracranial distance (ICD) equals approximately 0.1?m.
We used the noninvasive ultrasound technique to measure distance from the forehead skin surface to the occipital bone during acute head-down tilt (HDT). We hypothesized that this distance would increase with recumbency and HDT relative to head-up position due to elevation of ICP. Seven healthy subjects (ages 26-53) underwent the following tilt angles: 90? upright, 30?, 0?, -6?, -10?, -6?, 0?, 30? and 90?. Each angle was maintained for 1 min. Average path length from forehead to occipital bone increased 1.038 ? 0.207 mm (mean ? standard error) at 10? HDT relative to 90? upright values (Torikoshi et al., 1995). When the protocol was repeated using external compression over the ultrasound transducer to minimize changes in cutaneous and subcutaneous tissues during tilt, maximum ICD increase was 0.166 ? 0.038 mm. Application of external compression greatly reduces, but probably did not totally eliminate, cutaneous pooling between the transducer and frontal bone. Therefore, we have since developed technique and hardware modifications to eliminate extracranial tissue contributions to ICD measurements.
To establish the relationship between intracranial diameter and known changes in ICP, we studied two fresh cadavera (< 24 hrs. post-mortem), one female (age 83) and one male (age 93). Causes of death were not ICP-related. A ventricular cannula was inserted into a frontal horn of the lateral ventricle through a burr hole in the frontal bone. Direct ICP measurements were made via a fiber-optic, transducer-tipped catheter (Camino Laboratories, San Diego, CA) inserted into the subdural space through a separate burr hole. An ultrasound transducer was then secured with an elastic band to the side of the head. ICD was continuously monitored while ICP was altered in a stepwise fashion by infusion/removal of saline from the lateral ventricle. Changes in ICD, or distance from one side of the skull to the other, were calculated over the last 10 sec at each pressure level. In both cadavera, ICD increased linearly (ICD = 0.003(ICP) - 0.016, r=0.91) with graded elevation of ICP, such that an ICP change of 15 mmHg caused a skull expansion of 0.029 mm. Magnitudes of cranial expansion observed in these cadavera were similar to those reported in the literature for cats (Heisey and Adams, 1993) and our results supported qualitative findings of Hiefetz and Weiss (1981) in humans. Although only two cadavera were studied, these results clearly indicate that the ultrasound technique is capable of measuring the small changes in ICD resulting from changes (positive and negative) in ICP.
As stated previously, we have developed a new technique for quantifying changes in distance across the skull irrespective of changes in skin thickness. To evaluate the technique, four subjects underwent a tilt protocol similar to that outlined above. Briefly, subjects were secured in the upright posture to a tilt table, and an ultrasound transducer was secured to the side of the head using an elastic bandage. ICD was continuously monitored for one minute of each tilt angle: 90? HUT, -10? HDT, and 90? HUT (tilting from upright to -10? is estimated to increase ICP approximately 15 mmHg; Murthy et al., 1992). The change in ICD measured with our modified technique averaged 0.025 ? 0.008 mm at 10? HDT relative to upright values. Magnitudes of skull expansion observed in this pilot study agree well with results of our cadaver study. While further hardware developments are necessary to optimize the technique, our investigations to date support pulsed phase-lock loop ultrasound as a viable technique for measuring changes in intracranial dimensions and for monitoring ICP on Earth and in space.
ACKNOWLEDGEMENTS
We thank Karen Hutchinson, David Chang, and Dr. Gary Heit for technical assistance. Supported by NASA Ames Commercial Technology Office grant 307-51-12-12 and NASA grants 199-26-12-34 and 199-14-12-04.
REFERENCES
Heisey and Adams, Neurosurg. 33:869-877, 1993.
Hiefetz and Weiss, J. Neurosurg. 55:811-2, 1981.
Jennings et al., Aviat. Space Environ. Med. 64:423(27), 1993.
Miller et al., J Neurotrauma 9:S317-26, 1992.
Murthy et al., Physiologist 35:S184-5, 1992.
Torikoshi et al., J. Grav. Physiol., in press, 1995.
Yost and Cantrell, J. Acoust. Soc. Am. 91:1456-68, 1992.
I got that from here...
http://spacephysiology.arc.nasa.gov/abstracts/abstracts_96.html
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Also
The principle is based upon detecting skull movements which occur with fluctuations in ICP.
Although the skull is often assumed to be a rigid container with a constant volume, we and others have demonstrated that the skull moves on the order of a few ?m in association with arterial pressure (systolic/diastolic) and changes in ICP pulsations.
from here...
http://www-nesb.larc.nasa.gov/NNWG/VOL8.2/TASKS/ARC/arc82_1.html
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The principle is based upon detecting skull movements which occur with fluctuations in ICP (see figure 2). Although the skull is often assumed to be a rigid container with a constant volume, we and others have demonstrated that the skull moves on the order of a few ?m in association with changes in ICP.
from here...
http://www-nesb.larc.nasa.gov/NNWG/VOL7.1/TASKS/ARC/arc71_1.html
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