E-Cadherin Negative ductal carcinoma?

[pathstudent]

A resident ordered an e-cad on the wrong case and she ordered it on a grade one bland ductal carcinoma (BRS score of 3). The external and internal controls were strongly positive but the ductal carcinoma was flat out negative.

Has anyone seen this before? I know poorly differentiated ductals with lobular features can show reduced e-cad, but has anyone seen this in a well differentiated almost tubular carcinoma?

It looks like I may got me a case report!

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[Parts Unknown]

Let us know how that works out for you.

 

[Doctor Zaius]

The more breast I see, the more common aberrent ecadherin staining seems to become.

http://www.ncbi.nlm.nih.gov/pubmed/16287501

 

[Ruination]

p120 catenin. do it.