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This comes up every year as 4th years start to prepare in earnest for the spring board exam. Thanks to many people in this forum (you know who you are), myself and forum member Dr. Bloodmoney put together a list of errors in the Quick Compendium of Clinical Pathology. This list has been forwarded to the ASCP Press who assure me that subsequent printings of the book will have these errors expunged. I have had to edit this list several times, so if I accidentally deleted something I wouldn't be surprised, but it should be fairly complete.
Then I wrote the Companion book. Again forum members came to my aid and along with some of the senior residents in my residency program I composed a list of the errors/misprints/etc. in the Companion book. These have also been forwarded to ASCP Press.
The following are our lists. Please feel free to contribute, it helps us all.
Geo
Quick Compendium of Clinical Pathology, 2nd Edition
p. 2 - sentence reads "An assay that does not utilize NADH/NAD is that used to measure alkaline phosphatase", doesn't make sense.
p. 5 (column I) - "Page Disease" instead of Paget Disease.
p. 11 (column I) - "ensitive" instead of sensitive.
p. 12 (column I) - very end of column, "CKCK isoform ratios" should be "CK/CK isoform ratios"
p. 21 (Fig. 1.7) There are two Fig1.7c figures. It is stated in the second one "F1.7C(lambda) acute inflammation pattern" and should instead read "F1.7D acute inflammation pattern"
p. 23 (column I) - under tubular proteinuria pattern "results form" should be "results from"
p. 25 (T1.8) "Primary Hyperparathroidism" should be "Primary Hyperparathyroidism"
p. 26 (column II) - clinical presentation, bullet #2 "hyperphasphatemia" should be "hyperphosphatemia"
p. 29 (column I) - "Henderson-Hasselbach" should be spelled "Henderson-Hasselbalch". Also, technically, pK in the formula should be pKa.
p. 32 (column II) - "Tamm-Harsfall" should be "Tamm-Horsfall"
p. 33 (column I) - first bullet "andis not sensitive" should be "and is not sensitive"
p. 33 (column I) - second bullet - "Hook effect" should be "hook effect". The aforementioned "hook" is not eponymous, but rather refers to the graphed appearance of the paradoxical downward slope of the saturation curve when substrate concentration exceeds that of the detecting agent.
p. 34 (column I) - "FENA" should be "FENa"
p. 37 (column I) - first line "hCG in spontaneous abortion" should be formatted as a subject heading.
p. 37 (column I) - third bullet under hCG in gestational trophoblastic disease ""HCG" should be "hCG"
p. 40 (column II) bottom of the page - "systemic lupus erythrematosis" should be "...erythrematosus"
p. 43 (T1.18) "morphine" should be "heroin". then, the heroin metabolite should be "6-acetylmorphine", rather than "N-acetylmorphine"
p. 45 (column I) - barbituates don't have a significant role in the stimulation of GABA release. Rather they function by binding to the GABA receptor Cl- channel and facilitate the effects of GABA. Benzodiazepine drugs also bind to the GABA receptor and facilitate the opening of the Cl- channel. Barbituates work by keeping the channel open longer at a time, while benzos work by opening the channel more frequently. At high doses barbituates may directly stimulate the channel in the absence of GABA ligand.
p. 47 (column I) - "calculation of osmolal gap" should be "calculation of osmolar gap". Typically, the serum osmolality (osmoles/kg) is measured and osmolarity (osmoles/L) is calculated. In the context of the human body osmolality and osmolarity are roughly equivalent because the density of water (the major solvent) is 1 kg/L.
p. 49 (column II) - lead poisoning "delta (triangle) - ALA-dehydratase" should be a lower case delta.
p. 50 (column I) - laboratory methods "greater than or equal to 10 g/dL" should be "... 10 micrograms/dL". Similarly, "lead levels below 35 mg/dL" should be "...35 micrograms/dl"
p. 51 (column I) CO Poisoning - "it is produced endogenously from only one source: the breakdown heme." should be "....source: the breakdown of heme."
p. 57 - text states "G measurement, like total cholesterol" should read "TG measurement, like total cholesterol"
p. 60 (column I) "...and age >45 years for men and >55 years for women" should be "<45 years for men and <55 years for women"
p. 62 - table 1.29 should be titled "Hypoglycemia"
p. 63 (T1.30) "Lipoprotein Classes" should be "Glucose Intolerance Diagnosis" or something along those lines.
p. 70 (column II) CA27.29 (15-3). "trantuzumab" should be "trastuzumab"
p. 73 (column I) Markers of paraganglioma and pheochromocytoma - "vanillymandelic acid" should be "vanillylmandelic acid"
p. 76 (column I) hypothyroidism first bullet - "131I" is usually written as "I-131". "a-IFN" should be "[lower case Greek alpha]-IFN"
p. 80 - growth hormone excess causes gigantism in children and acromegaly in adults. The text states the opposite.
p. 81 (column I) bottom of page "b-endorphin" should be "[lower case Greek beta]-endorphin"
p. 83 (column II) protein "Tamm-Harsfall" should be "Tamm-Horsfall"
p. 87 - text states "typical twin transfusion peak". Should be "typical twin transferrin peak"
p. 88 (column I) pleural fluid chemistry "Meig Syndrome" should be "Meigs Syndrome"
p. 89 (T1.40) "Gross Appearance" is unnecessarily bold and there is no column header in the cell above.
p. 104 - text states hyperventilation causes hypercapnea. Should be hyperventilation causes hypocapnea.
p. 105 - table should indicate history of babesiosis OR Chagas.
p. 110 - Table 2.5 Rh Nomenclature - it is more helpful to list the Fisher-Race nomenclature as DCE, rather than CDE.
That being said, R0 should be Dce, not cDE
Rz should be DCE, not CDe
ry should be dCE, not Cde
p. 112 - under Lewis-related genes - text states "...while type 2 is only found on the red cell surface. There is no type 2 oligosaccharide on the red cell surface". It should state "There is no type 1 oligosaccharide..."
p. 113 (T2.8) - "Hi Genes" should be "H Genes", selection #8 has "ee" under Secretor Genes, should be "se"
p. 114 (column II) Kell antigens, 3rd bullet - "...is associated with shortened red blood cell survival, reduced deformability, and shortened survival" is confusing.
p. 116 (column I) HLA "See Chapter 7 for additional information", should be "See Chapter 6 for additional information"
p. 118 (column I) paragraph beginning "Clinical significance of detected antibodies" should be bold and italicized.
p. 121 (T2.11 #8) "autoconrol" should be "autocontrol"
p. 122 (column I) second bullet under "other unusual findings" "hus" should be "thus".
p. 125 "neonatal alloimmune thrombocytopenia" should be "neonatal alloimmune thrombocytopenic purpura (NATP)"
p. 130 (column II) "the shelf-life a washed red cells" should be "the shelf life of washed red cells"
p. 132 (column I) "Prevention of platelet-transmitted infection" should be bold and italicized.
"...required by AABB that a methods be" should be "...AABB that methods be..."
p. 132 uncer Granulocyte concentrates "Indications and Contraindications" should be bold and italicized.
p. 128-135 = a pervasive problem and also throughout several other sections of the book - there is no formatting consensus for the subheadings under each product - some are bold, some bold and italicized, some are neither.
p. 140 "Blood group antigens" placed in the middle of the page for no apparent reason
several pages - "N. meningitidis" is spelled "N. meningitides" throughout the chapter (e.g. p.157, column I bottom)
p. 164 (T3.4) - adenovirus has a superfluous "+" following it.
p. 165 bullet column I reference to T3.6 should be T3.5
p. 165 - Table 3.7 - lists papovaviruses as RNA viruses (should be DNA), picornaviruses as DNA viruses (should be RNA), rhabdoviridae is printed twice.
p. 168 (T3.9) incorrectly formatted in middle.
p. 185 sputum "Pneumocystis pneumoniae" is not an organism - "Pneumocystis carinii (jiroveci)" is the causative agent of PCP.
p. 197 (column I) echinococcus 1st bullet - unfinished sentence
p. 201 - Table 3.24 some of the descriptions are incorrect - "Mold form shows thick-walled yeasts with broad-based budding" - makes no sense. "Mold form shows mariner's wheel configuration", should be "yeast form shows mariner's wheel configuration".
p. 203 - Figure 3.15 lists "E. gypseum", should be "M. gypseum"
p. 242 (column I) - manual techniques - " 1 fL = 1 (subic microliter) = 10^-15 L" should read " 1 fL = 10^-9 microliter = 10^-15 L"
p. 242 (column II) - the red blood cell count (RBC) 3rd bullet "between 36 & 360 fL as red cells" should read "...with a volume between 36 & 360 fL..."
p. 243 (F4.1) - the axes may be reversed
p. 249 (column II) - bullets 5 & 6 - CD11b is NOT associated with Hairy cell leukemia. CD11c is.
p. 250 3rd bullet - the sentence is confusingly written and could be easily misinterpreted
p. 252 - Table 4.3 time needed and sensitivity blocks are reversed - PCR is faster and more sensitive.
p. 264 (T4.8) is all wrong - Beta-thalassemia syndromes
p. 266 - under pathologic cold agglutinins - states, "It may have anti-I, anti-i, anti-IH, anti-IH or anti-Pr specificity", should read "It may have anti-I, anti-i, anti-H, anti-IH, or anti-Pr specificity".
p. 267 top of column II - "...capacity to produce hemolysis only when incubated @ 2 different temperatures in vitro" - not true - binds at cold temperature and lyses at warm.
p. 284 - t(1;14) translocation is IgH- BCL10, not MALT1-IgH
p. 284 - Figure 4.10 flow cytometry has two CD5 v. CD19 plots - the one on the left is not follicular lymphoma, the one on the right could be. The caption mentions "Note coexpression of CD38 and CD10" but there is no CD38 v. CD10 plot.
p. 284 - MZL, under Molecular: text states "The t(1;14) translocation results in MALT1-IgH gene fusion". The text should read either "The t(1;14) translocation results in a bcl10-IgH gene fusion" or "The t(14;18) translocation results in the MALT1-IgH gene fusion". Both translocations are associated with MZL.
p.288 - text states "...Ig lambda (2p12) or IgK (22q11)". It should read "IgK (2p12) or Ig lambda (22q11)"
p. 294 - ATCL CD listed as both + and -
p. 296 - LGL diagnosis should be made with > 2 x 10^9 LGL/L
p. 297 Classical Hodgkin lymphoma is listed as a subheading of nodular lymphocyte predominant Hodgkind lymphoma, which it is NOT. It's more of a formatting problem, but could lead to misinterpretation.
p. 297-8 - the bulleting organization of the Hodgkins lymphoma is off, making it very confusing.
p. 302 (T4.29) - criteria for essential thrombocytosis should read platelets > or equal to 600 x 10^9/L
p. 332 (column I) - second bullet - lists causes of prolonged PTT, but normal PT "factors XII, XI, IX, VII" - deficiency of Factor VII will present with normal PTT, but prolonged PT. It should read "factors XII, XI, IX, VIII"
p. 389 (column I) - three steps of PCR listed as "denaturation, replication, then annealing" implies the sequential nature of a PCR reaction and should then read "denaturation, annealing, then extension or elongation".
p. 389 (column I) style issue - spectral karyotyping is most commonly referred to by the acronym "SKY" rather than "SKI"
p. 390 (column I) - description of Southern blotting is unclear and wrong.
p. 393 (column I) - Hardy-Weinberg equilibrium equation reads "p2 + 2pq + q2 = 1" should read "p2 + 2pq + q2 = 1". It is an binomial expansion of (p+q)2=1. If the formatting cannot be read it should be p(squared) + 2pq +q(squared) = 1.
p. 394 (column I) - Hereditary Cancer & Tumor Syndromes reads "...may be suspected based upon (1)... (2)... (2)...", should read "(1)... (2)... (3)..."
p. 394 (column II) - Turcot's Syndrome is listed as related to Lynch Syndrome (HNPCC). This is not true - Turcot's is related to familial adenosis polyposis and mutation of the APC gene.
p. 402 (column II) and Table 7.3 (p.403) The section heading and the table heading read "Applications of molecular studies in nonneoplastic disease" it should be "Applications of molecular studies in neoplastic disease"
p. 402 (column I) "manifestations iclude (sic)" should be "manifestations include"
p. 406 (column I) "<26 GAG repeats" should be "<26 CAG repeats"
p. 411 (column I) "The most common disease-causing mutation is delta508" - unfortunately I cannot use symbols with Google documents - the printed text uses lower case delta and should use upper case (the little triangle) - also on Table 7.5, p. 412 (column I)
p. 412 (column I, bottom) - the reference for Table 7.5 is placed after a description of the infections associated with cystic fibrosis. The reference should be placed at the end of the first paragraph, p. 411 (column I)
p. 423 T7.11 - "crit du chat" should be "cri du chat"
- CHARGE sequence "colomba" should be "coloboma"
p. 423 (column I) - "are considered permutations" should be "premutations"
p. 424 (column I) - "a fetoprotein" should be "alpha-fetoprotein"
p. 424 (column II) - "Nimmegen" should be "Nijmegen". it is spelled correctly at the subject heading, but not in the paragraph following.
p. 425 (column II) - under MELAS "interstingly" should be "interestingly"
p. 443 (column I) - Under the 1/3 rule states "Eg" should be "E.g." or "e.g."
Quick Compendium Companion for Clinical Pathology
note - numbers refer to question/answer numbers not page #s like above.
Chapter 1
1. answer should read "Rate of enzyme activity varies linearly with substrate concentration UNTIL enzyme is fully saturated.
23. should be "in vivo half life" instead of in vitro.
29. There are two Cs in the answer choices. (print only)
43. Choices A and D are identical; it's not really a mistake because both serous cystadenomas and solid-cystic tumors have identical amylase/CEA/CA19-9 pattern, but it's unusual to have two identical answer choices. Also extra A in question (at least online version)
78. 'hyperparthyroidism' should be hyperparathyroidism.
83. Choice B and the explanation. pH of 7.0. Everywhere pH 7.0 is (in both the question (choices B and C) and the explanation) it should be replaced by pH 7.40, such as the general range is 7.40 to 7.44
98. explanation: 'rhabomyolysis' should be rhabdomyolysis
143. The explanation states: 'The legal limits (of ethanol) vary by state, but are typically in the range of 0.8-1.0% should say .08-0.1%
146. The math is wrong. The answer should be 140x2 + 10/2.5 + 180/18 = 294. Change choice E in the question stem and answer to 294 mOsm/L and correct the misplaced decimal point in the formula, which should state ..180/18 rather than 180/1.8.
179. Last word of answer explanation should be months not weeks.
184. Choice B should read classical symptoms of diabetes and casual plasma glucose greater than 150 mg/dL.
206. answer explanation "Normetanephrine is metabolized to normetanephrine" should read norepinephrine is metabolized to normetanephrine.
209. 'Hyperthyroidism' in the question stem should be replaced with 'hypothyroidism'.
Chapter 2
67. explanation states: 'While both Factor V and Factor VII are labile in vitro, Factor VII is most labile in vivo.' It should say: 'While both Factor V and Factor VIII are labile in vitro, Factor VII is most labile in vivo.'
79. Which of the following indications is an appropriate usage of irradiated products?
A. cellular products to immunocompromised hosts
B. granulocyte concentrates to prevent neutropenic sepsis
C. prevention of alloimmunization in platelets
D. red blood cells to prevent CMV transmission
E. red blood cells to prevent recurrent febrile nonhemolytic transfusion reactions
A. cellular products to immunocompromised hosts.
The only clear indication for irradiation is to prevent transfusion-associated graft v. host disease. By irradiating white blood cells, they are rendered incapable of engrafting in an immunocompromised host. Irradiated products do not prevent CMV transmission, alloimmunization, or recurrent febrile non-hemolytic transfusion reactions, like leukoreduction does. Furthermore, while irradiation of granulocyte products is indicated to prevent graft v. host the irradiation does not prevent sepsis directly.
Chapter 3
39. Choice B in the question should be E. coli rather than gram negative anaerobes. Also the online answer lacks the complete answer. It should state C. N. meningitidis.
53. explanation should read "Coag-negative staph"
71. question stem should have 'except'.
* 91. in explanation, answer reads "B. the period between the disappearance of HBsAg and appearance of HBcAb.", but should read "... appearance of HBsAb"
* 181. question should be reworded from:
Which of the following dematiaceous molds is responsible for chromoblastomycosis?
A. Fonseca
B. Phialophora
C. Cladosporiom
D. Wangiella
E. Exophiala
to:
Which of the following dematiaceous molds is responsible for chromoblastomycosis?
A. Fonseca
B. Phialophora
C. Cladosporium
D. A & B
E. A, B, C
also, in the explanation "dematiaceous" is misspelled.
* 187. The question should read "Which of the following stains the cell wall of cryptococcus?"
* 196. The explanation should be changed to:
B. white.
MacConkey agar is both selective for gram-negative organisms and differential for lactose fermenters v. non-lactose fermenters. The lactose non-fermenters appear as white colonies, and include organisms such as Pseudomonas, Serratia, and Burkholderia
* 229. question: "What is the optimal growth temperature for Pseudomonas?" should be changed to "Growth at which of the following temperatures helps differentiate Pseudomonas aeruginosa" from most other species of Pseudomonas? and the explanation should be changed to:
"Pseudomonas aeruginosa can grow at a temperature that would induce the expression of heat-shock proteins in most other bacteria. Despite the wide temperature growth range for Pseudomonas, P. putida and P. fluorescens will not grow at 42°C."
Chapter 4
* 74. Question choice A "--/-alpha" should be "--/alpha alpha"
* 75. Question choice C "lot Hct" should be "low Hct"
* 98. Explanation reads "...coated with antibodies rather than delivered to ..." and should be changed to "...coated with antibodies then delivered to..."
* 112. Explanation reads "...as neutropenia with affecting lymphocyte production..." and should be changed to "...as neutropenia without affecting lymphocyte production..." Also, Kostmann is misspelled as "Kostmannn" throughout the explanation (at least in the electronic version).
Chapter 5
43. type 2N is best considered autosomal recessive, not dominant, as the answer indicates. The correct answer should be A. autosomal recessive and the explanation should reflect that, i.e. the last word in the answer explanation should be recessive.
Chapter 6
50. explanation should read "All are associated with drug-induced lupus, which in turn is highly associated with anti-nuclear and anti-histone antibodies.
51. last line of explanation should read "activate cellular immunity", rather than active cellular immunity.
Chapter 7
* 25. Answer written as "B. 85%." should be "C. 85%"
* 45. Explanation is confusing. It reads "Birt-Hogg-Dube is not associated with pseudohermaphroditism and renal tumors, but Denys-Drash syndrome is.", but is probably better stated as "Birt-Hogg-Dube is not associated with the combination of pseudohermaphroditism and renal tumors, but Denys-Drash syndrome is.", since BHD is associated with renal tumors, but not associated with pseudohermaphroditism.
* 60. Explanation reads "...with Ewing sarcoma is t(11;22)(q24;a12)." and should read "...with Ewing sarcoma is t(11;22)(q24;q12)."
* 63. In the answer "Beckwith-Weidemann" should be spelled "Beckwith-Wiedemann"
* 65. The question is wrong. Currently it reads:
Synovial sarcoma is associated with the translocation t(X;18) resulting in a SYT-SSX fusion. Which of the following statements is correct?
A. SYT-SSX2 is associated more with biphasic synovial sarcoma
B. SYT-SSX1 is associated more with monophasic synovial sarcoma
C. SYT-SSX2 is associated more with monophasic synovial sarcoma
D. SYT-SSX1 is associated more with biphasic synovial sarcoma
E. none of the above are true
and should be changed to:
Synovial sarcoma is associated with the translocation t(X;18) resulting in a SYT-SSX fusion. Which of the following statements is correct?
A. SYT-SSX1 is associated more with biphasic synovial sarcoma
B. SYT-SSX2 is associated more with monophasic synovial sarcoma
C. SYT-SSX1 is associated more with monophasic synovial sarcoma
D. A & B
E. A, B, C
and the answer will be "D. A & B." Same explanation.
* 72. Explanation states "Normal (unaffected non-carrier) individuals usually have more than 26 CAG repeats..." but should read "Normal (unaffected non-carrier) individuals usually have less than 26 CAG repeats"
* 125. Explanation states ""loss of parental DNA leads to Prader-Willi" it should be "loss of paternal DNA leads to Prader-Willi"
Then I wrote the Companion book. Again forum members came to my aid and along with some of the senior residents in my residency program I composed a list of the errors/misprints/etc. in the Companion book. These have also been forwarded to ASCP Press.
The following are our lists. Please feel free to contribute, it helps us all.
Geo
Quick Compendium of Clinical Pathology, 2nd Edition
p. 2 - sentence reads "An assay that does not utilize NADH/NAD is that used to measure alkaline phosphatase", doesn't make sense.
p. 5 (column I) - "Page Disease" instead of Paget Disease.
p. 11 (column I) - "ensitive" instead of sensitive.
p. 12 (column I) - very end of column, "CKCK isoform ratios" should be "CK/CK isoform ratios"
p. 21 (Fig. 1.7) There are two Fig1.7c figures. It is stated in the second one "F1.7C(lambda) acute inflammation pattern" and should instead read "F1.7D acute inflammation pattern"
p. 23 (column I) - under tubular proteinuria pattern "results form" should be "results from"
p. 25 (T1.8) "Primary Hyperparathroidism" should be "Primary Hyperparathyroidism"
p. 26 (column II) - clinical presentation, bullet #2 "hyperphasphatemia" should be "hyperphosphatemia"
p. 29 (column I) - "Henderson-Hasselbach" should be spelled "Henderson-Hasselbalch". Also, technically, pK in the formula should be pKa.
p. 32 (column II) - "Tamm-Harsfall" should be "Tamm-Horsfall"
p. 33 (column I) - first bullet "andis not sensitive" should be "and is not sensitive"
p. 33 (column I) - second bullet - "Hook effect" should be "hook effect". The aforementioned "hook" is not eponymous, but rather refers to the graphed appearance of the paradoxical downward slope of the saturation curve when substrate concentration exceeds that of the detecting agent.
p. 34 (column I) - "FENA" should be "FENa"
p. 37 (column I) - first line "hCG in spontaneous abortion" should be formatted as a subject heading.
p. 37 (column I) - third bullet under hCG in gestational trophoblastic disease ""HCG" should be "hCG"
p. 40 (column II) bottom of the page - "systemic lupus erythrematosis" should be "...erythrematosus"
p. 43 (T1.18) "morphine" should be "heroin". then, the heroin metabolite should be "6-acetylmorphine", rather than "N-acetylmorphine"
p. 45 (column I) - barbituates don't have a significant role in the stimulation of GABA release. Rather they function by binding to the GABA receptor Cl- channel and facilitate the effects of GABA. Benzodiazepine drugs also bind to the GABA receptor and facilitate the opening of the Cl- channel. Barbituates work by keeping the channel open longer at a time, while benzos work by opening the channel more frequently. At high doses barbituates may directly stimulate the channel in the absence of GABA ligand.
p. 47 (column I) - "calculation of osmolal gap" should be "calculation of osmolar gap". Typically, the serum osmolality (osmoles/kg) is measured and osmolarity (osmoles/L) is calculated. In the context of the human body osmolality and osmolarity are roughly equivalent because the density of water (the major solvent) is 1 kg/L.
p. 49 (column II) - lead poisoning "delta (triangle) - ALA-dehydratase" should be a lower case delta.
p. 50 (column I) - laboratory methods "greater than or equal to 10 g/dL" should be "... 10 micrograms/dL". Similarly, "lead levels below 35 mg/dL" should be "...35 micrograms/dl"
p. 51 (column I) CO Poisoning - "it is produced endogenously from only one source: the breakdown heme." should be "....source: the breakdown of heme."
p. 57 - text states "G measurement, like total cholesterol" should read "TG measurement, like total cholesterol"
p. 60 (column I) "...and age >45 years for men and >55 years for women" should be "<45 years for men and <55 years for women"
p. 62 - table 1.29 should be titled "Hypoglycemia"
p. 63 (T1.30) "Lipoprotein Classes" should be "Glucose Intolerance Diagnosis" or something along those lines.
p. 70 (column II) CA27.29 (15-3). "trantuzumab" should be "trastuzumab"
p. 73 (column I) Markers of paraganglioma and pheochromocytoma - "vanillymandelic acid" should be "vanillylmandelic acid"
p. 76 (column I) hypothyroidism first bullet - "131I" is usually written as "I-131". "a-IFN" should be "[lower case Greek alpha]-IFN"
p. 80 - growth hormone excess causes gigantism in children and acromegaly in adults. The text states the opposite.
p. 81 (column I) bottom of page "b-endorphin" should be "[lower case Greek beta]-endorphin"
p. 83 (column II) protein "Tamm-Harsfall" should be "Tamm-Horsfall"
p. 87 - text states "typical twin transfusion peak". Should be "typical twin transferrin peak"
p. 88 (column I) pleural fluid chemistry "Meig Syndrome" should be "Meigs Syndrome"
p. 89 (T1.40) "Gross Appearance" is unnecessarily bold and there is no column header in the cell above.
p. 104 - text states hyperventilation causes hypercapnea. Should be hyperventilation causes hypocapnea.
p. 105 - table should indicate history of babesiosis OR Chagas.
p. 110 - Table 2.5 Rh Nomenclature - it is more helpful to list the Fisher-Race nomenclature as DCE, rather than CDE.
That being said, R0 should be Dce, not cDE
Rz should be DCE, not CDe
ry should be dCE, not Cde
p. 112 - under Lewis-related genes - text states "...while type 2 is only found on the red cell surface. There is no type 2 oligosaccharide on the red cell surface". It should state "There is no type 1 oligosaccharide..."
p. 113 (T2.8) - "Hi Genes" should be "H Genes", selection #8 has "ee" under Secretor Genes, should be "se"
p. 114 (column II) Kell antigens, 3rd bullet - "...is associated with shortened red blood cell survival, reduced deformability, and shortened survival" is confusing.
p. 116 (column I) HLA "See Chapter 7 for additional information", should be "See Chapter 6 for additional information"
p. 118 (column I) paragraph beginning "Clinical significance of detected antibodies" should be bold and italicized.
p. 121 (T2.11 #8) "autoconrol" should be "autocontrol"
p. 122 (column I) second bullet under "other unusual findings" "hus" should be "thus".
p. 125 "neonatal alloimmune thrombocytopenia" should be "neonatal alloimmune thrombocytopenic purpura (NATP)"
p. 130 (column II) "the shelf-life a washed red cells" should be "the shelf life of washed red cells"
p. 132 (column I) "Prevention of platelet-transmitted infection" should be bold and italicized.
"...required by AABB that a methods be" should be "...AABB that methods be..."
p. 132 uncer Granulocyte concentrates "Indications and Contraindications" should be bold and italicized.
p. 128-135 = a pervasive problem and also throughout several other sections of the book - there is no formatting consensus for the subheadings under each product - some are bold, some bold and italicized, some are neither.
p. 140 "Blood group antigens" placed in the middle of the page for no apparent reason
several pages - "N. meningitidis" is spelled "N. meningitides" throughout the chapter (e.g. p.157, column I bottom)
p. 164 (T3.4) - adenovirus has a superfluous "+" following it.
p. 165 bullet column I reference to T3.6 should be T3.5
p. 165 - Table 3.7 - lists papovaviruses as RNA viruses (should be DNA), picornaviruses as DNA viruses (should be RNA), rhabdoviridae is printed twice.
p. 168 (T3.9) incorrectly formatted in middle.
p. 185 sputum "Pneumocystis pneumoniae" is not an organism - "Pneumocystis carinii (jiroveci)" is the causative agent of PCP.
p. 197 (column I) echinococcus 1st bullet - unfinished sentence
p. 201 - Table 3.24 some of the descriptions are incorrect - "Mold form shows thick-walled yeasts with broad-based budding" - makes no sense. "Mold form shows mariner's wheel configuration", should be "yeast form shows mariner's wheel configuration".
p. 203 - Figure 3.15 lists "E. gypseum", should be "M. gypseum"
p. 242 (column I) - manual techniques - " 1 fL = 1 (subic microliter) = 10^-15 L" should read " 1 fL = 10^-9 microliter = 10^-15 L"
p. 242 (column II) - the red blood cell count (RBC) 3rd bullet "between 36 & 360 fL as red cells" should read "...with a volume between 36 & 360 fL..."
p. 243 (F4.1) - the axes may be reversed
p. 249 (column II) - bullets 5 & 6 - CD11b is NOT associated with Hairy cell leukemia. CD11c is.
p. 250 3rd bullet - the sentence is confusingly written and could be easily misinterpreted
p. 252 - Table 4.3 time needed and sensitivity blocks are reversed - PCR is faster and more sensitive.
p. 264 (T4.8) is all wrong - Beta-thalassemia syndromes
p. 266 - under pathologic cold agglutinins - states, "It may have anti-I, anti-i, anti-IH, anti-IH or anti-Pr specificity", should read "It may have anti-I, anti-i, anti-H, anti-IH, or anti-Pr specificity".
p. 267 top of column II - "...capacity to produce hemolysis only when incubated @ 2 different temperatures in vitro" - not true - binds at cold temperature and lyses at warm.
p. 284 - t(1;14) translocation is IgH- BCL10, not MALT1-IgH
p. 284 - Figure 4.10 flow cytometry has two CD5 v. CD19 plots - the one on the left is not follicular lymphoma, the one on the right could be. The caption mentions "Note coexpression of CD38 and CD10" but there is no CD38 v. CD10 plot.
p. 284 - MZL, under Molecular: text states "The t(1;14) translocation results in MALT1-IgH gene fusion". The text should read either "The t(1;14) translocation results in a bcl10-IgH gene fusion" or "The t(14;18) translocation results in the MALT1-IgH gene fusion". Both translocations are associated with MZL.
p.288 - text states "...Ig lambda (2p12) or IgK (22q11)". It should read "IgK (2p12) or Ig lambda (22q11)"
p. 294 - ATCL CD listed as both + and -
p. 296 - LGL diagnosis should be made with > 2 x 10^9 LGL/L
p. 297 Classical Hodgkin lymphoma is listed as a subheading of nodular lymphocyte predominant Hodgkind lymphoma, which it is NOT. It's more of a formatting problem, but could lead to misinterpretation.
p. 297-8 - the bulleting organization of the Hodgkins lymphoma is off, making it very confusing.
p. 302 (T4.29) - criteria for essential thrombocytosis should read platelets > or equal to 600 x 10^9/L
p. 332 (column I) - second bullet - lists causes of prolonged PTT, but normal PT "factors XII, XI, IX, VII" - deficiency of Factor VII will present with normal PTT, but prolonged PT. It should read "factors XII, XI, IX, VIII"
p. 389 (column I) - three steps of PCR listed as "denaturation, replication, then annealing" implies the sequential nature of a PCR reaction and should then read "denaturation, annealing, then extension or elongation".
p. 389 (column I) style issue - spectral karyotyping is most commonly referred to by the acronym "SKY" rather than "SKI"
p. 390 (column I) - description of Southern blotting is unclear and wrong.
p. 393 (column I) - Hardy-Weinberg equilibrium equation reads "p2 + 2pq + q2 = 1" should read "p2 + 2pq + q2 = 1". It is an binomial expansion of (p+q)2=1. If the formatting cannot be read it should be p(squared) + 2pq +q(squared) = 1.
p. 394 (column I) - Hereditary Cancer & Tumor Syndromes reads "...may be suspected based upon (1)... (2)... (2)...", should read "(1)... (2)... (3)..."
p. 394 (column II) - Turcot's Syndrome is listed as related to Lynch Syndrome (HNPCC). This is not true - Turcot's is related to familial adenosis polyposis and mutation of the APC gene.
p. 402 (column II) and Table 7.3 (p.403) The section heading and the table heading read "Applications of molecular studies in nonneoplastic disease" it should be "Applications of molecular studies in neoplastic disease"
p. 402 (column I) "manifestations iclude (sic)" should be "manifestations include"
p. 406 (column I) "<26 GAG repeats" should be "<26 CAG repeats"
p. 411 (column I) "The most common disease-causing mutation is delta508" - unfortunately I cannot use symbols with Google documents - the printed text uses lower case delta and should use upper case (the little triangle) - also on Table 7.5, p. 412 (column I)
p. 412 (column I, bottom) - the reference for Table 7.5 is placed after a description of the infections associated with cystic fibrosis. The reference should be placed at the end of the first paragraph, p. 411 (column I)
p. 423 T7.11 - "crit du chat" should be "cri du chat"
- CHARGE sequence "colomba" should be "coloboma"
p. 423 (column I) - "are considered permutations" should be "premutations"
p. 424 (column I) - "a fetoprotein" should be "alpha-fetoprotein"
p. 424 (column II) - "Nimmegen" should be "Nijmegen". it is spelled correctly at the subject heading, but not in the paragraph following.
p. 425 (column II) - under MELAS "interstingly" should be "interestingly"
p. 443 (column I) - Under the 1/3 rule states "Eg" should be "E.g." or "e.g."
Quick Compendium Companion for Clinical Pathology
note - numbers refer to question/answer numbers not page #s like above.
Chapter 1
1. answer should read "Rate of enzyme activity varies linearly with substrate concentration UNTIL enzyme is fully saturated.
23. should be "in vivo half life" instead of in vitro.
29. There are two Cs in the answer choices. (print only)
43. Choices A and D are identical; it's not really a mistake because both serous cystadenomas and solid-cystic tumors have identical amylase/CEA/CA19-9 pattern, but it's unusual to have two identical answer choices. Also extra A in question (at least online version)
78. 'hyperparthyroidism' should be hyperparathyroidism.
83. Choice B and the explanation. pH of 7.0. Everywhere pH 7.0 is (in both the question (choices B and C) and the explanation) it should be replaced by pH 7.40, such as the general range is 7.40 to 7.44
98. explanation: 'rhabomyolysis' should be rhabdomyolysis
143. The explanation states: 'The legal limits (of ethanol) vary by state, but are typically in the range of 0.8-1.0% should say .08-0.1%
146. The math is wrong. The answer should be 140x2 + 10/2.5 + 180/18 = 294. Change choice E in the question stem and answer to 294 mOsm/L and correct the misplaced decimal point in the formula, which should state ..180/18 rather than 180/1.8.
179. Last word of answer explanation should be months not weeks.
184. Choice B should read classical symptoms of diabetes and casual plasma glucose greater than 150 mg/dL.
206. answer explanation "Normetanephrine is metabolized to normetanephrine" should read norepinephrine is metabolized to normetanephrine.
209. 'Hyperthyroidism' in the question stem should be replaced with 'hypothyroidism'.
Chapter 2
67. explanation states: 'While both Factor V and Factor VII are labile in vitro, Factor VII is most labile in vivo.' It should say: 'While both Factor V and Factor VIII are labile in vitro, Factor VII is most labile in vivo.'
79. Which of the following indications is an appropriate usage of irradiated products?
A. cellular products to immunocompromised hosts
B. granulocyte concentrates to prevent neutropenic sepsis
C. prevention of alloimmunization in platelets
D. red blood cells to prevent CMV transmission
E. red blood cells to prevent recurrent febrile nonhemolytic transfusion reactions
A. cellular products to immunocompromised hosts.
The only clear indication for irradiation is to prevent transfusion-associated graft v. host disease. By irradiating white blood cells, they are rendered incapable of engrafting in an immunocompromised host. Irradiated products do not prevent CMV transmission, alloimmunization, or recurrent febrile non-hemolytic transfusion reactions, like leukoreduction does. Furthermore, while irradiation of granulocyte products is indicated to prevent graft v. host the irradiation does not prevent sepsis directly.
Chapter 3
39. Choice B in the question should be E. coli rather than gram negative anaerobes. Also the online answer lacks the complete answer. It should state C. N. meningitidis.
53. explanation should read "Coag-negative staph"
71. question stem should have 'except'.
* 91. in explanation, answer reads "B. the period between the disappearance of HBsAg and appearance of HBcAb.", but should read "... appearance of HBsAb"
* 181. question should be reworded from:
Which of the following dematiaceous molds is responsible for chromoblastomycosis?
A. Fonseca
B. Phialophora
C. Cladosporiom
D. Wangiella
E. Exophiala
to:
Which of the following dematiaceous molds is responsible for chromoblastomycosis?
A. Fonseca
B. Phialophora
C. Cladosporium
D. A & B
E. A, B, C
also, in the explanation "dematiaceous" is misspelled.
* 187. The question should read "Which of the following stains the cell wall of cryptococcus?"
* 196. The explanation should be changed to:
B. white.
MacConkey agar is both selective for gram-negative organisms and differential for lactose fermenters v. non-lactose fermenters. The lactose non-fermenters appear as white colonies, and include organisms such as Pseudomonas, Serratia, and Burkholderia
* 229. question: "What is the optimal growth temperature for Pseudomonas?" should be changed to "Growth at which of the following temperatures helps differentiate Pseudomonas aeruginosa" from most other species of Pseudomonas? and the explanation should be changed to:
"Pseudomonas aeruginosa can grow at a temperature that would induce the expression of heat-shock proteins in most other bacteria. Despite the wide temperature growth range for Pseudomonas, P. putida and P. fluorescens will not grow at 42°C."
Chapter 4
* 74. Question choice A "--/-alpha" should be "--/alpha alpha"
* 75. Question choice C "lot Hct" should be "low Hct"
* 98. Explanation reads "...coated with antibodies rather than delivered to ..." and should be changed to "...coated with antibodies then delivered to..."
* 112. Explanation reads "...as neutropenia with affecting lymphocyte production..." and should be changed to "...as neutropenia without affecting lymphocyte production..." Also, Kostmann is misspelled as "Kostmannn" throughout the explanation (at least in the electronic version).
Chapter 5
43. type 2N is best considered autosomal recessive, not dominant, as the answer indicates. The correct answer should be A. autosomal recessive and the explanation should reflect that, i.e. the last word in the answer explanation should be recessive.
Chapter 6
50. explanation should read "All are associated with drug-induced lupus, which in turn is highly associated with anti-nuclear and anti-histone antibodies.
51. last line of explanation should read "activate cellular immunity", rather than active cellular immunity.
Chapter 7
* 25. Answer written as "B. 85%." should be "C. 85%"
* 45. Explanation is confusing. It reads "Birt-Hogg-Dube is not associated with pseudohermaphroditism and renal tumors, but Denys-Drash syndrome is.", but is probably better stated as "Birt-Hogg-Dube is not associated with the combination of pseudohermaphroditism and renal tumors, but Denys-Drash syndrome is.", since BHD is associated with renal tumors, but not associated with pseudohermaphroditism.
* 60. Explanation reads "...with Ewing sarcoma is t(11;22)(q24;a12)." and should read "...with Ewing sarcoma is t(11;22)(q24;q12)."
* 63. In the answer "Beckwith-Weidemann" should be spelled "Beckwith-Wiedemann"
* 65. The question is wrong. Currently it reads:
Synovial sarcoma is associated with the translocation t(X;18) resulting in a SYT-SSX fusion. Which of the following statements is correct?
A. SYT-SSX2 is associated more with biphasic synovial sarcoma
B. SYT-SSX1 is associated more with monophasic synovial sarcoma
C. SYT-SSX2 is associated more with monophasic synovial sarcoma
D. SYT-SSX1 is associated more with biphasic synovial sarcoma
E. none of the above are true
and should be changed to:
Synovial sarcoma is associated with the translocation t(X;18) resulting in a SYT-SSX fusion. Which of the following statements is correct?
A. SYT-SSX1 is associated more with biphasic synovial sarcoma
B. SYT-SSX2 is associated more with monophasic synovial sarcoma
C. SYT-SSX1 is associated more with monophasic synovial sarcoma
D. A & B
E. A, B, C
and the answer will be "D. A & B." Same explanation.
* 72. Explanation states "Normal (unaffected non-carrier) individuals usually have more than 26 CAG repeats..." but should read "Normal (unaffected non-carrier) individuals usually have less than 26 CAG repeats"
* 125. Explanation states ""loss of parental DNA leads to Prader-Willi" it should be "loss of paternal DNA leads to Prader-Willi"
