1) Before as
@Goro always likes to point out, a letter of intent was a promise with no requirement to be kept. If schools start requiring use of "intent to enroll" via AMCAS, an applicant better make sure there is a single LOI that matches it.
2) I wonder if the constant talk of making WL/Alternate a formal status within AMCAS will also follow this path. That is, if AMCAS will add a WL tool where students can declare "intent to accept if offered." From an enrollment planning perspective, which is what these tools are for, it would make great sense.
3) Taking that further, it would make sense to have an AMCAS function for "applicant update" that could be sent out to all schools applied to. Something like a 700 character field.