Factor V Leiden : UW is wrong here!

[lordman]

Please check question 4112. Choice B should be wrong! It states that Factor V Leiden causes prolonged PT and PTT! I remember from step 1 that both will be normal even with adding factor C. Any thoughts?

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[Phloston]

Well I can't access UW anymore, but PT and PTT wouldn't be prolonged in FVL. Activated protein C resistance would lead to increased proportions of activated factor V and a normal, or even low, aPTT. And I don't see how PT would even relate here.

 

[lordman]

Well I can't access UW anymore, but PT and PTT wouldn't be prolonged in FVL. Activated protein C resistance would lead to increased proportions of activated factor V and a normal, or even low, aPTT. And I don't see how PT would even relate here.

Thanks man. After some search I found that they can both normal, or prolonged, but never decreases.

 

[Phloston]

Thanks man. After some search I found that they can both normal, or prolonged, but never decreases.

Can you post whatever link you found?

 

[docphd]

I see they changed the explanation in uworld also yesterday for this question; they have now taken out that line.

 

[CaliAtenza]

I see they changed the explanation in uworld also yesterday for this question; they have now taken out that line.

Yeah I just saw that. All it says is that Lupus anticoagulant could prolong PTT, but Factor V Leiden is obviously thrombogenic.

 

[lordman]

Can you post whatever link you found?

UW fixed it. Here is the link for you:
http://www.pathologystudent.com/?p=229

I see they changed the explanation in uworld also yesterday for this question; they have now taken out that line.

Yep

Yeah I just saw that. All it says is that Lupus anticoagulant could prolong PTT, but Factor V Leiden is obviously thrombogenic.

 

[CaliAtenza]

UW fixed it. Here is the link for you:
http://www.pathologystudent.com/?p=229

nice explanation on that page .

 

[Phloston]

Any peer-reviewed articles on this stuff?

 

[enhancers]

so in the Functional aPC resistance assays, is PTT normal, decreased or increased? if pt has factor V leiden

 

[teehees]

I hate it when the pathophysiology doesn't match with the clinical picture