I failed Calculus the first time a took it, a big fat F. Granted I had made mostly A's and a few B's and nothing lower than that. I was at a place in my life where I was unsure where I would end up career-wise. I was majoring in Chemistry and minoring in Math. I quit going to Calculus and missed the drop date. It was too late once I found out so I was put on academic probation as a consequence. This was in the Fall of 2005 and it was all that I needed to get my act together. I switched my major to Biology and minor to Chemistry. I decided on pharmacy that following spring. Luckily I had gotten Physics and most Chemistry classes out of the way. I have waited to re-take Calculus this semester because I have been so scared that I would fail again....so far, with a lot of hard work and extra hours of studying, I have made a 100 on my first two tests. I think I just needed to prove it to myself that I am capable, I just wasn't willing back in '05. I applied in November and I felt great about everything on my transcript...except for that stinking F!!! I was so scared it would be my downfall and everyone I worked with heard about it all the time. Long story but it has a great ending....I was placed in early decision at Texas Tech and at UNM. My number one choice was Tech and I was accepted last week. It has made it all worth it. I think the adcomm knows if you made a bad decision, especially if it was a one time thing. It all depends on everything else you have going for you: work experience, total GPA, science GPA, LORs, EC's, etc. Don't let a mistake get you down, you just might surprise yourself like I did 🙂