first aid p 214 - Atrophy

[anbuitachi]

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first aid has so few words!

on page 214, 2013, it says Increased pressure (nephrolithiasis).
and occlusion of secretory ducts (cystic fibrosis)

Can someone explain what this has to do w/ atrophy..? especially the nephrolithiasis one, thanks!

 

[Zzmed]

nephrolithiasis --> back up of urine --> increased intraluminal pressure (in ureters, calyces then tubules) --> atrophy of the renal tubules (destruction of epithelium etc etc)

cystic fibrosis --> more thickened secretions (eg in pancreatic ducts) --> occlusion of ducts --> accumulation of secretory products --> damage and atrophy due to increased pressure (or chemical damage --> pancreatic enzymes)

I hope it will help you. Tell me if you got this...

 

[anbuitachi]

nephrolithiasis --> back up of urine --> increased intraluminal pressure (in ureters, calyces then tubules) --> atrophy of the renal tubules (destruction of epithelium etc etc)

cystic fibrosis --> more thickened secretions (eg in pancreatic ducts) --> occlusion of ducts --> accumulation of secretory products --> damage and atrophy due to increased pressure (or chemical damage --> pancreatic enzymes)

I hope it will help you. Tell me if you got this...

thank you!

 

[Pinkleton]

To add to what zzmed said for nephrolithiasis, remember that the backpressure of urine squeezes renal blood vessels shut which caused ischemia and hence HYPOXIA. Without O2 the cells undergo atrophy

 

[Zzmed]

To add to what zzmed said for nephrolithiasis, remember that the backpressure of urine squeezes renal blood vessels shut which caused ischemia and hence HYPOXIA. Without O2 the cells undergo atrophy

Good point! Congrats.

 

[okokok]

Reviving an old thread to ask - can anyone explain to me why these mechanism cause atrophy ("reduction in the size and/or number of cells" FA 2015 p225) rather than necrosis? Since the reasoning is due to lack of oxygen, I'd expect infarction.

 

[Transposony]

Reviving an old thread to ask - can anyone explain to me why these mechanism cause atrophy ("reduction in the size and/or number of cells" FA 2015 p225) rather than necrosis? Since the reasoning is due to lack of oxygen, I'd expect infarction.

It's all about the time of onset.
Rapid onset>>>Necrosis (cells can't cope with the sudden loss/reduction in blood supply)
Slow onset>>> Atrophy (cells try to cope with the gradual reduction in blood supply)

 

[okokok]

It's all about the time of onset.
Rapid onset>>>Necrosis (cells can't cope with the sudden loss/reduction in blood supply)
Slow onset>>> Atrophy (cells try to cope with the gradual reduction in blood supply)

Appreciate it, thanks!