Folinic acid vs Folate

[Confusant]

What's the difference? As far as I know, folinic acid is the "active" form of folate, therefore it should be administered in preference of the other in some situations?



Thanks!

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[Praziquantel86]

What's the difference? As far as I know, folinic acid is the "active" form of folate, therefore it should be administered in preference of the other in some situations?



Thanks!

Not exactly. Its a reduced form of folate that doesn't require activation by dihydrofolate reductase. Its used in situations like high-dose methotrexate therapy, where the body is unable to activate folic acid due to inhibition of DHFR. Its also used in combination with 5-FU in some chemo regimens, but as far as I know, its due to an unrelated effect.

 

[newspeak]

Thank you so much