I attempted to schedule my classes so that I had open days where I could go on interviews. I was lucky enough to arrange my schedule so I had no classes on Mon or Wed, and would use the Mon off-day for as many out of town interviews as I could, so that I could fly in on Sunday afternoon/evening and be fresh and ready for the next day. The Wed was good for interviews I could drive or take public transportation to (I'm in Chicago). It was also nice to have those days off since I could for the most part focus completely on my interviews without having to worry about where I needed to be at what time,etc. Of course, there were times I had to miss class, etc for interviews since some schools will only give you one specific day, but usually profs are pretty understanding about it - especially if they enounter a lot of students who apply to med school. Bottom line is, unfortunately there will be some a$$es who won't let you make up stuff. But the best piece of advice I can give about having to miss - LET YOUR PROFS KNOW BEFOREHAND!!!! The one thing profs absolutely HATE is when you know weeks in advance but only let them know a day or two before. It looks irresponsible and immature and makes them not want to be helpful/lenient with you. If you let them know in advance, however, I find they tend to be much more appreciative and accomodating.