General molecular chem was better for me because I enjoyed it more. General quantitative chem (solution stoichiometry, thermodynamics, chemical equilibrium, acid-base equilibria, etc.) is not really harder, but I found it more difficult just because I find it less interesting. Analytical Chemistry (chromatography,spectroscopy, Mass Spec, etc.) can be difficult, but I enjoyed it.
Analytical chemistry is not hard. However, the lab is more difficult to get a good grade because you have to do a lot of titrations to find the real percent of the substance in the unknown. I remember my professor will give anyone a Zero if your finding is 5% different from the literature value.