Does grignard always add to the less substituted C, when there's a situation in which there is more than 1 C to choose from?
Grignard
- Thread starter 123321
- Start date
- Joined
- Feb 9, 2014
- Messages
- 77
- Reaction score
- 17
On DAT, usually you only have one carbon to attack, especially when carbonyl molecules are involved.
When dealing with epoxides, it is depends on whether the condition is acidic or basic. The nuc attacks more substituted carbon under acidic condition and the oxygen gets protonated in the process. In basic conditions, the less substituted carbon is preferred.
When dealing with epoxides, it is depends on whether the condition is acidic or basic. The nuc attacks more substituted carbon under acidic condition and the oxygen gets protonated in the process. In basic conditions, the less substituted carbon is preferred.
- Joined
- Mar 12, 2005
- Messages
- 4,786
- Reaction score
- 3,486
I am assuming you are talking about epoxides. The Grignard will always add to the less substituted carbon.
Hope this helps
Dr. Romano
