It's nearly impossible to know the stresses, pressures, and the resulting lifestyle of a profession which demands an 80+ hour workweek when it's just an idea, or a dream. You can't really blame a spouse for not understanding what 80+ hours entails until they actually experience it.
Anyway, are spouses just a commodity to you? Are they something to be tossed away or traded on a whim? Or, are they every bit as important an investment as your profession? Any kind of a pre-nup would probably be incomplete without a clause describing your love for your profession over the professed love of your future spouse. I mean, to be fair he/she should know that they are and will always be second best, right? If they're fine with that, then obviously there should be no problems in the future!
Nothing wrong with working in surgery, don't get me wrong, but to treat your significant other's feelings and attitudes with such contempt as many in here have done is ridiculously short-sighted, and certainly not conducive to a stable and healthy home suitable for children or a lasting marriage.