I really enjoyed some of my honors college classes, but not all of them. At my school, the University of Oklahoma, there is a class, that was in the top five of the best classes that I took as an undergraduate, called Literature and Medicine. It was awesome and also a nice way to get to read literature instead of the science text books I was used to reading for the past three years. As others mentioned, honors classes usually are more reading and writing-based, which can be a nice contrast to science. The class was taught by an English teacher and a physician who teaches at OU Med school. I really learned a lot and came to develop my ideas about the kind of service as a physician I would want to offer, about compassion, ethics, etc. Taking this class made being part of the honors program worth it. Literature and Medicine classes are starting to become part of the medical school curriculum across the country, so I feel really fortunate to have had the opportunity. BUT I couldn't say that being an honors student has really helped bolster my application, as I have been fairly unsuccessful in the allopathic field, for several reasons I won't get into. It probably depends upon the school how favorably they look at being an honors student. I will have to say I am proud of myself for graduating with honors (magna cum laude this May; Finally!) because it is something few people do. Just my thoughts on the advantages and disadvantages of being an honors student.
. Yes a lot of the classes were humanities but I felt it was a nice distraction from my typical pre med courses. I also liked the smaller classes and in my opinion better teachers. I was also in classes where the people were interesting, had a lot to say, and wanted to learn, it made class very interesting. 
