I'll speak from the <3.0 category. I had two interviews that I attended. The first was closed-file, single interviewer with student. We did not focus very much at all on my past experience, and more on my interest in pharmacy, and whether I would make a successful pharmacy school candidate.
The second was open-file, single interviewer. The beginning focused alot on my bad grades and withdrawals. I had prepared for this aspect and was able to clearly state my reasons for the low grades and prove my upward progression. I was able to push the interview into my experiences outside of school where my background was a little more polished.
Basically, if you are a good communicator, with a little tact you should be able to drive the interview where you want it to go while having the interviewer believe they're the ones who drove you there.