how n why mitochondrial damage can cause incomplete reduction of oxygen?

[sylhet]

---

Members do not see this ad.

I am really having hard time to understand how reperfusion injury cause cell damage. I understand its due to more production ROS, reactive oxygen species. And the free radicals are produced in reperfused tissue as a result of mitochondrial damage, causing incomplete reduction of oxygen that is coming to cell.(Robbins and Cotran 8e, Page 24; Rapid Review 3e, Page 07). I just know it but i dont know how. Would someone PLEASE explain a bit more elaborately how mitochondrial damage can cause incomplete reduction of oxygen at first place?? I am desperatly looking for the answer but i didnt find it explained in any textbooks i read. Kindly help. 😡

 

[loveoforganic2]

Oxidative phoshorylation, to go to completion, requires complex V (which requires a proton gradient). With mitochondrial membrane damage, complexes I-IV can continue to function, producing reactive oxygen species, but none of these will be neutralized to water by complex V d/t disruption of the proton gradient

 

[sylhet]

Oxidative phoshorylation, to go to completion, requires complex V (which requires a proton gradient). With mitochondrial membrane damage, complexes I-IV can continue to function, producing reactive oxygen species, but none of these will be neutralized to water by complex V d/t disruption of the proton gradient

So, with mitochondrial damage, complexes might remain in their position but the proton gradient will loss as they will go out of the mitochondrion. right?

 

[loveoforganic2]

So, with mitochondrial damage, complexes might remain in their position but the proton gradient will loss as they will go out of the mitochondrion. right?

Actually, I think I was a bit confused, as it's actually complex IV that catalyzes the formation of water. I'll let someone else chime in