Although I have not taken the class yet, many of my friends have and they all were overwhelmed with the amount of information that was presented to them. So make sure you read before lecture, PAY ATTENTION in lecture, and read after. I know it sounds like a ridiculous amount of studying but it will really pay off also, do not just memorize, try to create relationships between all the different systems of the body etc. The advisers at my school said to me "if you don't do well in systems phys you will have a very hard time in med school". I don't know how true that holds but I'm assuming they're telling the truth.