while I was working at a hospital full time when I was going thru interview season so I didn't have to hide it, I definitely didn't take much time off. i't tiring but it can be done. Fri interviews we're best, because I could take a red-eye thurs night, prep in the hotel, interview in the am, then take my time coming home. Mid week interviews were harder, but can be done with a single day off. I remember taking a half day (i was working 12's) on a tues, hoping a flight to Roanoke, VA, hr drive to Blacksburg for VCOM, hotel for the night, Interview Wed, fly back home that night, hr drive back to my house, 3 hrs of sleep, back to work.
Tough schedule, but you can sneak single days in there. Just make sure if you do this your interview skills don't suffer for it. I made up the sleep on weekends. GL!