Hydrochlorothiazide? (WARNING: X-Men Wolverine spoiler)

This forum made possible through the generous support of SDN members, donors, and sponsors. Thank you.
The Angriest Bird

The Angriest Bird

Full Member
15+ Year Member
Joined
Sep 24, 2007
Messages
424
Reaction score
6
Members do not see this ad.
WARNING: This post contains spoiler for the recent movie X-Men Origins: Wolverine



***************************





For those who've seen the movie, at one point Silverfox said Victor faked her death by injecting her with hydrochlorothiazide. When I was in the theatre, I was like "did I just hear hydrochlorothiazide?"

That's a pretty neat off-the-label use of a diuretic!
 
Uh, yeah, I caught that as well. Pretty glaring to anyone who is on top of their renal and/or cardiovascular pharm/phys. These guys need to check their medical facts before casually throwing around stuff like that.
 
I caught this as well. I just thought I was missing some side effect of the drug that I was completely unaware of at high doses. (aka tried not to let medical school reality take over my movie experience)

You would think a multi-million dollar movie like that would have a consulted SOMEONE about that
 
Ha yes, I know! I just saw that with some med school buddies, and we nerdily broke out laughing. It's like,

"we gave her some hydrochlorothiazide. she had to pee really bad!"
"you bastard!"
 
I just figured that's why her clothes were all wet.:laugh:
 
My gf (another MS2) and I were watching this together. When this happened, we both just looked at each other with a WTF expression.
 
Yeah, I couldn't believe they would throw in a med use like that in such a realistic movie. I nearly walked out when they said that at the end.
 
if it made her so hypotensive that he cudnt feel a pulse i can see how that's not tooo far a stretch, though he's kinda lame for not making sure she at least had a wound of some sort
 
Hydrochlorothiazide sounds impressive, but is easy to say. Pretty sure that was all they were looking for. Regretfully, they don't tailor these sci-fi flicks to us (educated) nerds.
 
It's actually pretty responsible of them to use something that sounds impressive but is otherwise harmless.

Otherwise I can already see the headlines at cnn.com: "Man Arrested for Urinating in Public After Failure in Staging Death; Blames X-Men: Origins" you know you've seen it before, humans lol 😀
 
Last edited:
I never thought of it that way. I agree though, they could very well just be protecting themselves. Not that bad of a train of thought. People are stupid and will do anything they see in a movie. I guarantee there's some 30 year old idiot with swords duct-taped to his arms right now cutting up a tree in his Mom's backyard.
 
Wow, I didn't even catch this because I was too busy thinking "Wait, what? He didn't notice she wasn't actually wounded...AND HE MUST HAVE LEFT HER THERE? WHAT?".

Yeah. Now, spironolactone, on the other hand...
 
neuroprotector said:
Ha yes, I know! I just saw that with some med school buddies, and we nerdily broke out laughing. It's like,

"we gave her some hydrochlorothiazide. she had to pee really bad!"
"you bastard!"
Click to expand...

hahahaha. Cool to see everyone has been like wtf about this. lol
 
mildlyneurotic said:
It's actually pretty responsible of them to use something that sounds impressive but is otherwise harmless.

Otherwise I can already see the headlines at cnn.com: "Man Arrested for Urinating in Public After Failure in Staging Death; Blames X-Men: Origins" you know you've seen it before, humans lol 😀
Click to expand...

That's one way of thinking about it. But I think they could have just as easily said "we drugged her...made it seem like her heart stopped" and not ever specified what was given.
 
I went "WHAT?!!" during the movie, drawing quite a bit of attention. hehe
 
Death by hypokalemia!!!!!!!!!!!!!!!!!!!1111111111111111!
 
elderjack21 said:
Yeah, I couldn't believe they would throw in a med use like that in such a realistic movie. I nearly walked out when they said that at the end.
Click to expand...

I am going to interpret this as one of the best tongue-in-cheek comments that I've read in a while.👍
 
southernIM said:
That's one way of thinking about it. But I think they could have just as easily said "we drugged her...made it seem like her heart stopped" and not ever specified what was given.
Click to expand...

that's no fun :laugh:

real life edward scissorhands said it all lol
 
mildlyneurotic said:
It's actually pretty responsible of them to use something that sounds impressive but is otherwise harmless.

Otherwise I can already see the headlines at cnn.com: "Man Arrested for Urinating in Public After Failure in Staging Death; Blames X-Men: Origins" you know you've seen it before, humans lol 😀
Click to expand...

You sir are a genius. When my classmates and I(all MS4s) watch it we started laughing and afterwards were trying to come up with some way that would cause the effect and what drug could actually do what they said HCTZ did. We never even thought about how many dumb people out there try and imitate movies. Reading your post reminded me of the football movie, I think it was call "the Program" when they laid down on the road and kids got killed trying to do that in real life.
 
How about the fact that HCTZ doesn't even come as an injection...not to mention the crazy sun sensitivity if she was laying there in the sun at a theoretically high dose to knock her out.
 
sure hydrochlorothiazide is easy to say, but why not adenosine? lol

only problem is short half-life...
 
VolPharmD said:
How about the fact that HCTZ doesn't even come as an injection...not to mention the crazy sun sensitivity if she was laying there in the sun at a theoretically high dose to knock her out.
Click to expand...
Steps to making HCTZ injectable:
1. Crush HCTZ tablets in distilled water.

Ta daaaaa!
 
MilkmanAl said:
Steps to making HCTZ injectable:
1. Crush HCTZ tablets in distilled water.

Ta daaaaa!
Click to expand...

I wish making drugs was so easy! That was a good joke! I cannot imagine the burn you would get if you didn't have the correct pH and isotonicity of the injection...if you want an example just inject the vial that you would mix the Zostavax lyophilized powder with and you will see what I mean (that is what one of my preceptors did once). Just for completeness purposes the only real thiazide diuretic for injection that I know of is Chlorothiazide.

Enjoy! 😀
 
Well, I mean, I wasn't getting too concerned with the practicality of the administration since they did put freaking molten metal into him. A ghetto-rigged HCTZ injection sounds like like a week at the spa comparatively.
 
spicedmanna said:
Uh, yeah, I caught that as well. Pretty glaring to anyone who is on top of their renal and/or cardiovascular pharm/phys. These guys need to check their medical facts before casually throwing around stuff like that.
Click to expand...

Yeah, but "hydrochlorothiazide" sure sounds impressive doesn't it? I mean, it sounds like something you could fake your death with. I let it go since I was also pretending that injecting metal alloy into your bones wouldn't destroy your bone marrow. I do wonder where Wolverine makes all that blood that he bleeds.
 
I saw Wolverine when it first came out. This was before I started school and learned anything about HCTZ. I just rewatched it since I saw First Class recently and thought, well I haven't seen this in a while. I didn't even catch the HCTZ injection part until this time around. Stopped her heart?! I might have not cared 2 years ago, but now I can't help but think, who came up with that?!
 
leopharm0917 said:
I saw Wolverine when it first came out. This was before I started school and learned anything about HCTZ. I just rewatched it since I saw First Class recently and thought, well I haven't seen this in a while. I didn't even catch the HCTZ injection part until this time around. Stopped her heart?! I might have not cared 2 years ago, but now I can't help but think, who came up with that?!
Click to expand...

Producers who think "if people actually get a hold of this drug, whats the worst that can happen?"
 
I just wanna say that for me (who has no knowledge of the movie) this is the greatest/funniest thread title of all time.
 
I was hoping this thread was going to be about the gaffe in X-Men: First Class.

I had a few drinks with a PGY-5 radiology resident before going in and we both started cracking up when we heard the medical gaffe. Anyone remember what it was?
 
cowme said:
Fair. Xmen: the last stand was definitely worse
Click to expand...

Agreed, what a crap movie

I did pick up on this, I vaguely recall. I guess they die by pissing themselves into hypokalemia.
 
You must log in or register to reply here.

Similar threads

M
Subtle Warning About Residency During Interviews
Replies
2
Views
3K
eforest
E
G
Anesthesia to X specialty after pgy1 stories
Replies
6
Views
2K
pablo213
pablo213
C
Any video series to watch for step 1 x-ray interpretation?
Replies
5
Views
699
Hippocratesintraining
H
GettinAfterIt
  • Locked
x
Replies
20
Views
11K
jj22901
jj22901
P
Is there an X vs Y thread for residency programs ?
Replies
1
Views
1K
obiwan
obiwan
Top