I have 2 questions about congenital adrenal hyperplasia
According to Pathoma--
salt wasting occurs in 21 hydroxylase deficiency, but if there is NO salt wasting then Dr. Sattar says that it is due to a 11 hydroxylase "P.R.O.B.L.E.M."
q1- Doesnt he mean salt wasting doesnt occur because there is an 11 hydroxylase PRESENCE, not a problem? (because 11 hydroxylase is the 2nd line (after 21hydroxylase) that makes aldosterone.
q2- Sattar states that pregnelone-->aldosterone via 21 hydroxylase, and then MORE aldosterone via 11 hydroxylase, so my question is- Is 21 hydroxylase required to make alodsterone in order for 11 hydroxylase to work, or can 11 hydroxylase, itself, produce aldosterone, even if 21 hydroxylase is deficient? (because that would be the REASON why there is no salt wasting right)?
i hope i make sense, this is very confusing. pg 169 on pathoma. video starts at 12:33 on congenital adrenal hyperplasia in endocrine section of pathoma.
gracias.
According to Pathoma--
salt wasting occurs in 21 hydroxylase deficiency, but if there is NO salt wasting then Dr. Sattar says that it is due to a 11 hydroxylase "P.R.O.B.L.E.M."
q1- Doesnt he mean salt wasting doesnt occur because there is an 11 hydroxylase PRESENCE, not a problem? (because 11 hydroxylase is the 2nd line (after 21hydroxylase) that makes aldosterone.
q2- Sattar states that pregnelone-->aldosterone via 21 hydroxylase, and then MORE aldosterone via 11 hydroxylase, so my question is- Is 21 hydroxylase required to make alodsterone in order for 11 hydroxylase to work, or can 11 hydroxylase, itself, produce aldosterone, even if 21 hydroxylase is deficient? (because that would be the REASON why there is no salt wasting right)?
i hope i make sense, this is very confusing. pg 169 on pathoma. video starts at 12:33 on congenital adrenal hyperplasia in endocrine section of pathoma.
gracias.
