Assuming Y2K doesn't end civilization Senator McCain is going to get the nomination. Americans don't like dynasties. After all the First Lady is running for Senator in New York, she will never run for president.
Saying that a Republican will win next year is like saying that in 2008 some black dude nobody has heard of will become president. Read: it is never going to happen.
And nice choice on the pets.com, it's as eternal as the world trade center.