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Important Cardiology trials summarized!

Discussion in 'Cardiology' started by NMed, Jan 25, 2011.

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  1. NMed

    NMed 7+ Year Member

    Sep 26, 2008
    Hey guys,

    I looked around online but couldn't find a good reference on summaries of important cardiology trials for any resident/aspiring cardiologist like myself. So I created one myself and would like it share it for fellow studentdoctor networkees..

    Any suggestions/error corrections are appreciated. If I missed a particular trial, please let me know and I'll try to add them to next updates of the document. Mods please sticky if appropriate.

    Enjoy and hope it helps!


    Wikipedia link: Cardiology Trials Quick Review

    Attached Files:

    Last edited: May 16, 2011
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  3. Terex

    Terex 7+ Year Member

    Apr 13, 2009
    Thanks a lot Man!!!:)
  4. cool c

    cool c 2+ Year Member

    Jul 2, 2007
    thanks a bunch
  5. NMed

    NMed 7+ Year Member

    Sep 26, 2008
    glad to help!
  6. Dreemer005

    Dreemer005 5+ Year Member

    Mar 6, 2007
    United States
    You should make a wiki page for it. Would be neat to fill in additional information about the study, such as inclusion/exclusion, etc.
  7. KaLiMaN


    Jan 22, 2011
    Thank you very helpful information.
  8. NMed

    NMed 7+ Year Member

    Sep 26, 2008
    yep..wiki page is coming along as well.. once it's up, user contribution will make adding such info much faster .. :)

    you're welcome!
  9. LatinGeorge


    Jan 26, 2008

    perhaps this could help outhttp://www.incirculation.net/whatswhat/11078_0.aspx

    those r the clasic trials who r relevant in each day for a cardiologist..

    hope it helps:thumbup:
  10. tkim

    tkim 10 cc's cordrazine 10+ Year Member

    Aug 2, 2002
    New England
  11. DrStevo

    DrStevo 5+ Year Member

    Apr 2, 2007
    Anybody have any good websites or references for principles or basics of left heart cath. Thanks
  12. NMed

    NMed 7+ Year Member

    Sep 26, 2008
    thanks, it's a great resource; it helped me alot when i was intinially starting the project

    thanks! i'll check it out
  13. whatevr


    Mar 9, 2010

    this is a great summary!
    iam a pgy 1 & hard core cards fan(though much ignorant) but no mentor or any research in my program. love research though still wrapping my head around how to s of a research.. i have to start an research from scratch here & have no idea where to begin, and dont now enough cards to come up with a good idea..
    any guidance or collaboration with any one doing any kind or form of research will be much appreciated!
  14. KaLiMaN


    Jan 22, 2011

    I would encourage you to talk to somebody working on cardiac imaging, either echo, nuclear, CT and/or MRI. There are tons of thins you could do doing retrospective analysis on any of these imaging modalities.
  15. hcn22

    hcn22 10+ Year Member

    Jun 16, 2004
    Amazing! Thanks so much for sharing! :D
  16. PercAVR


    Apr 25, 2011
    Thank you for the great review.

    However, be careful with your conclusions. For example, you wrote:

    In fact, COGENT trial (published in NEJM in 10/2010) that evaluated a COMBINATION pill consistent of clopidogrel 75mg/Omeprazole 20 mg could not rule out cardiovascular risks. The study was significantly underpowered to evaluate safety of this drug combo. It was terminated prematurely and the mean follow up period was 106 days, while in previous observational studies the adverse outcomes from concomitant use of Omeprazole and Plavix have been reported up to 12 mos.
    The study did NOT evaluate high risk patients fro UGIB, as you mentioned in your summary. They were excluded from study. COGENT evaluated only intermediate risk population (those on NSAIDS and positive for H. pylori).
    Again, the study used a combination pill which pharmacokinetics differ from real clopidogrel and omeprazole, used as separate preparations. Also, they used a fixed dose of Omeprazole of 20 mg. In previous ex-vivo studies it has being shown that omeprazole effect on inhibition of clopidogrel is dose dependent (it inhibits cytochrome CYP2C19 , that is responsible for producing an active clopidogrel metabolite), so it is likely, that the higher doses of Omeprazole (40 mg qd or bid) in combination with Plavix would result in higher rates of adverse cardiac events.
    Thus, I would probably exclude COGENT from my list at all since this is an inadequate trial that does not provide any convincing evidence beyond the fact that Omerazole has protective effect on GI tract (we already kinda knew that)
    Last edited: Apr 25, 2011
  17. NMed

    NMed 7+ Year Member

    Sep 26, 2008
    Wikipedia article created!


    Please edit appropriately.

    happy to help!

  18. PercAVR


    Apr 25, 2011
    Very well done job, man!
  19. PHD_2007

    PHD_2007 Senior Member 7+ Year Member

    Thank you so much for this page!!! I will be a PGY-1 in a few months and I am very interested in Cardiology!!!! This is a Great Thread. I have been trying to find a mentor but I haven't been very successful. If there are any cardiologists or fellows that would like a good mentee please let me know!!! Thanks!!! :)
  20. dienekes88

    dienekes88 7+ Year Member

    Jan 21, 2008
    Well done!

    Regarding ACCORD, it's important to note that the ACCORD cohort had a mean duration of diabetes of almost 10 years and had multiple risk factors for cardiovascular disease. The consensus statement from the ACCF, ADA, and AHA published in Diabetes Care is that newly diagnosed patients should still be treated to a target of <7% with aggressive management of other risk factors: lipids, bp, etc. Older patients with longer duration of illness, greater morbidity associated with hypoglycemic events, etc. are allowed more lax control. According to UKPDS and DCCT, the cardiovascular benefits of improved glycemic control don't show up until about 9 years out, but improvements in microvascular morbidity are seen early on.

    Also, it might be good to include ACCOMPLISH.

    Thirdly, I think in the BARI-2D trial, PCI and CABG were used for different cohorts with patients in the CABG cohort having more extensive disease and left main (or left main equivalent disease). The CABG cohort actual did better with fewer MIs/deaths, so prompt revascularization given no contraindications is preferred.
    Last edited: May 30, 2011
  21. jphoward


    Dec 27, 2011
    Hi there,

    I've actually made something quite similar to this and on line at http://cardiologytrials.org

    Your document is a great resource, too. There are definitely a few I've missed out that you've got!
  22. CanIMakeIt

    CanIMakeIt Fellow 10+ Year Member

    Oct 8, 2003
    There are apps for iPhone for these as well
    - ACS Trials
    - CHF Trials

    i think each one is $2.99

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