Nah. Unless you suddenly shift to a completely depressed negative mood when talking about clinical experience or something. 😉 But no, at least for me as an interviewer, it's fun and interesting to see an applicant break out of their shell a little and talk about something they are passionate about outside of medicine. I can get a sense from the rest of the interview, and the adcom can tell from the app, how serious someone is about pursuing medicine, but outside passions might not be conveyed as strongly in a short blurb on AMCAS.