I'm applying to both MD and DO programs this year. I got into a DO program near my home, and I have two waitlists to MD programs. If I get admissions off these waitlists, I still wouldn't be 100% set on leaving my DO program to go to one of these MD programs for many reasons (family/friends, support system, rotation opportunities in CA). My brother's an MD and he told me to pick the DO program, even if I get off the MD waitlists, because its my cheapest and most established option.
From my experiences, the only people who look down on DOs are ******* pre-meds who are in love with the glamorization that "MD" letters bring and old MD's who are on the brink of retiring. I spoke to a psychiatrist MD (about 70-80 years old) about DO programs, and he told me to reapply if I don't get into MD programs because "DO programs are doctors of osteopathic medicine. OSTEO. BONE. They focus on bones."
In general, I think it depends upon the individual. If the MD letters are really that important to you, and you need it to boost your ego, then go MD. However, you are most likely going into medicine for the wrong reasons.