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when they ask for a weakness are they asking for a character flaw, a weakness in your application, or what could potentially make you a bad doctor?
for instance, I could say either that I'm timid when challenged by authority, or I could point out several of my application weaknesses (low GPA, etc)
I would second this. Your weakness should be something that you are actively trying to change or make better. If you are saying you work too hard or are too honest...then you should be trying to actively change that... which would mean starting to lie and be lazy. Obviously, not a good idea.
Everyone *surely* has a weakness..... GPA low (you techincally cant change that, but you can be working on study habits, have had an upwards trend of GPA, etc), have a hard time concentrating on reading material (i.e. youd rather do and learn than read and learn), are quiet or timid at times when you really wish you would jump forward and be the leader, etc etc... all these are character flaws that do not flaw your integrity and can all be at least somewhat polished to make you better at whatever you do. Other weaknesses that you may have such as... well I drink too much on the wkends, or I've slept with too many people, etc are best to just not be brought up!
I think the most important thing in an interview is to be able to list a weakness you have, how you have improved that weakness thus far, and how you will continue to work on it and get better as time goes on... and its an extra gold star if you can relate how the position you are applying for can help it.
Just an example: When asked this same question, I always said I am often on the quiet/shy side when I first meet someone, but after I get to know them, I am good. I took interviewing skills courses before applying to medical school, I took speech in college.. both worked on this flaw.... and as residency interviews came I was able to list the same flaw, but MUCH improved previously by providing patient care, acting as president of a large school group, etc... but is still something I hope to work on as I am a resident. Its a weakness, I recognize it, I have improved it, and am continuing to do so...
Good luck..