Lack of Y chromosome

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Didn't know where else to post this. So I'm on my psych rotation, and I was seeing an inpatient who is basically bipolar, currently manic with psychosis and very grandiose ideas. He was picked up by the cops for driving drunk over 100 mph, and he threatened to kill the cops with guns he apparently had stashed in his house. Probably antisocial personality. Anyhow, I'm reading through the old computer records as he has been hospitalized 4 times, and in a note from about 3 years ago, some doctor says something to the effect of "he was found to have a lack of Y chromosome".

Of course my preceptor didn't really know as he hasn't thought about this stuff for about 10 years. How is it possible for a phenotypic male to lack a Y chromosome. He most certainly does NOT have Turner's syndrome. I was thinking that maybe the doc slipped up in the note and he has XYY syndrome, which would help explain his aggressiveness, etc. Any thoughts???

 

[velo]

lack of a Y chromosome is a devastating condition that afflicts approximately 50% of the population

 

[71263]

CAH, perhaps?

 

[DougFlutie]

lack of a Y chromosome is a devastating condition that afflicts approximately 50% of the population

Outstanding. 👍

 

[scotttennis]

lack of a Y chromosome is a devastating condition that afflicts approximately 50% of the population

...affecting driving ability and regularly influencing behavior. Sounds like the doctor got it right! ;-)

 

[delicatefade]

...affecting driving ability and regularly influencing behavior. Sounds like the doctor got it right! ;-)

True. 👍

 

[go1981]

it might be because his Sex Determining Region, which determines whether you are male or not and is usually on the Y chromosome, recombined and is now on the X chromosome. so he is XX, but he is a male because he now has the Sex Determining Region on one of his X chromosomes.

 

[FutureDocDO]

it might be because his Sex Determining Region, which determines whether you are male or not and is usually on the Y chromosome, recombined and is now on the X chromosome. so he is XX, but he is a male because he now has the Sex Determining Region on one of his X chromosomes.

SRY gene

during meiosis a piece of a Y chromosome transfers to the X, and is carried on into the sperm

 

[delicatefade]

googled that and it makes sense. they never taught us about it in genetics at my school, or if they did it was dumped loooooong ago. thanks

 

[FutureDocDO]

googled that and it makes sense. they never taught us about it in genetics at my school, or if they did it was dumped loooooong ago. thanks

It's one those little detail that we all complain about on exams because most professors just mention it for a split second in their lectures. Fortunately, my undergrad professor was good and anal about minutia.

 

[71263]

SRY gene

during meiosis a piece of a Y chromosome transfers to the X, and is carried on into the sperm

Damn, I learned that a few months ago and already forgot it. That cant be good 🙁