We talk a lot about giving our long term patients "line holidays" when there's a question of bacteremia (but unproven). So we pull their lines, get by with peripheral lines, then replace the CVCs, trialysis catheters, etc, after 24 hours. If there's no culture-proven bacteremia, is there any evidence to say that you need to wait 24 hours before replacing lines? Why couldn't you just replace them right away? Either the bloodstream is infected or it's not. I just feel like I'm missing something and maybe it's institutional dogma rather than EBM. Although... in my mind, if there's no bloodstream infection or catheter infection there's no need to pull the lines in the first place if your plan is to replace them shortly thereafter.