I have come across few scripts for Lipitor 10mg once a week??
Whats the point? Am I missing something here?
Whats the point? Am I missing something here?
-
CycleTrack and SDN are teaming up to make medical school admissions more transparent and accessible! Read the announcement to learn how we’re supporting the future of CycleTrack’s free application-tracking tools .
Lipitor Once weekly
Started by ohiopharmacist
Get help with your application
Use all the free resources available to you from SDN: articles, guides, expert advising, forums discussions, and school research.
D
deleted205891
I found this:
http://www.ncbi.nlm.nih.gov/pubmed/11978260
It appears that 20mg once a week did have some lipid-lowering effect. 10mg though? I don't know.
http://www.ncbi.nlm.nih.gov/pubmed/11978260
It appears that 20mg once a week did have some lipid-lowering effect. 10mg though? I don't know.
They're trying to achieve some lipid lowering while avoiding myalgias in sensitive patients.
Rosuva would be a better choice due to higher potency and lower lipophillicity.
thanks but wow...n=24,the study exhibits some REAL power. The physician was upset that I even questioned him but whatever I filled it anyway.
I give Drs a lot more leeway in what I'll fill is their misguided prescription is useless as opposed to potentially harmful. But 10mg qw is eh, try pravastatin first
Who knows what they already tried. I look at QW or BIW dosing as the last resort before non-statin txs. I have had luck with CoQ10 and prava or fluva with a couple of ppl, although not getting them to LDL goal. I figure it's better to have some lowering, some pleiotropic effects rather than nothing, even if the LDL is not where it "should" be.
Have you guys seen some older physicians write for Prava 20mg BID? I have seen this a few times among older docs and they had nothing to say except, "it has worked in my patients before and is safe so just fill it!" lol
Only data I can find is from the original trial that got pravastatin approved years ago but the BID dosing arm didn't see any significant lipid lower effect.
Interesting, just curious what you folks have seen..
Only data I can find is from the original trial that got pravastatin approved years ago but the BID dosing arm didn't see any significant lipid lower effect.
Interesting, just curious what you folks have seen..
Yup, seen it. And I had the same result when I tried to get the dr to change it.
Another argument you can try on drs, other than efficacy, is the improved adherence you get from once-daily dosing. (Though if the efficacy argument doesn't work on them, adherence is probably also a no-go.)
Re the O/P: I'm assuming this is primary and not 2ndary prevention.
See my post above. There is more to preventing CV events than just LDL lowering. Case in point, ezetimibe.
I'm of two minds in those sorts of situations. On the one hand, it makes no sense to dose a statin BID (other than fluva). If you are concerned about it not being a true QD med, use simva.
OTOH, if the patient tolerates it, it's cheap now and it's doing the job...it ain't broke.
Adherence would be the only argument, I would think. Is the patient refilling on time? If not, I would use that angle.
No primary prevention data for niacin, side effects not so fun, can raise glucose.
BAS - side effects not so fun, multiple daily dosing, cost, no data in women (not to say it doesn't work, but you know...)
Whoa, isn't the half life of lipitor ~14 hours with it's action half life longer than that by a bit?
So after 1-2 days that lipitor wouldn't be having much of an effect at all.
I don't see why someone would be on this unless they have tried every other lipid lowering agent like others suggested (bile acid sequesterants, the other statins, niacin, etc...). Or perhaps their LDL is only a little elevated.
So after 1-2 days that lipitor wouldn't be having much of an effect at all.
I don't see why someone would be on this unless they have tried every other lipid lowering agent like others suggested (bile acid sequesterants, the other statins, niacin, etc...). Or perhaps their LDL is only a little elevated.
I can't find it at the moment, but I read a study where patients who were on a normal dose of a statin for a while, and then were d/c'd still showed some improvements in mortality. Assumption was that it helped to clear out the past 50 years of plaque, so their body was in comparable shape to those who continued on the statins. Obviously it'd probably be better to stay on the drug, but it sort of gives some credit for the "something is better than nothing" dosing of QW.
Also, when I first saw the title, I thought this was going to be a crazy patent extender.
Also, when I first saw the title, I thought this was going to be a crazy patent extender.
coq10 is a scam.
Who says?
Educate me, oh wise one.😀 (if your response is to read the clinical trials, I already know them, well).
Last edited:
