Malaria and Burkitt's Lymphoma

Discussion in 'Internal Medicine and IM Subspecialties' started by jakstat33, May 2, 2004.

  1. jakstat33

    jakstat33 Senior Member
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    why is malaria associated with burkitt's lymphoma in endemic areas?
     
  2. Kalel

    Kalel Membership Revoked
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    Malaria is a chronic infection, and that probably activates more B-cells and increases the risk of those who are susceptible (eg people co-infected with EBV who are genetically pre-disposed) to develop burkitt's lymphoma.
    http://www.ncbi.nlm.nih.gov/entrez/...ve&db=pubmed&dopt=Abstract&list_uids=10777011
    http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=1972671
    http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=2998987
     
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  3. hammersmith

    hammersmith Member
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    Like most other cancers, Burkitt's lymphoma needs initiater and promoter. Both
    EBV and malarial parasite act as promoters at different stages.
     

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