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MCAT AAMC BB Section Bank #20

GreatSageDoc

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2+ Year Member
Mar 1, 2018
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Hello,

I don't understand why we would look at the initial velocity instead of vmax for competitive inhibition. Wouldn't it be simpler to look at the vmax and see if there is a difference?

Please help.

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GreatSageDoc

New Member
2+ Year Member
Mar 1, 2018
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21
  1. Pre-Medical
In Michaelis-Menten kinetics, you obtain Vmax by measuring the initial velocity of the reaction over increasing substrate concentrations. Vmax = the initial velocity at higher substrate concentration.
This is making a lot more sense now, Thanks! Just to make sure I got it right, using the high initial Vo would make it so that we can test for both Vmax AND Km inhibited and uninhibited and THEN we know what we are looking at in terms of inhibition no matter what kind it is (e.g. competitive, uncompetitive, noncompetitive)?
 
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