Sorry, I'm not a very frequent poster or I would have responded to one of your earlier threads. As people have told you, it's a strange road from PhD to MD - no matter how well you did in grad school, undergrad grades and MCATs are still what they're looking at. I think it's due to the large number of applicants each school has. I found that schools didn't even know I was IN grad school until I got an interview. My undergrad grades were not super-med-student stellar, and my MCAT score was good, but certainly nowhere near as great as the stuff you see posted on SDN. First, make sure you want to do this and that it is for the right reasons. I assume that's already the case, so I won't dwell on it. I saw that some people are recommending retaking undergrad courses, and I'm not sure how I feel about it. In a way, it may get you some more interviews, but it's also kind of a waste of time and money in my eyes. Many premeds are extremely concentrated on the end result (get in to best med school, get in to best residency), rather than the worthwhile journey - as far as I'm concerned, if you passed a class, why take it over just to prove you can remember more the second time around? Why not take a different class and learn something new? You're already doing that, being in graduate school. Anyway, I would use it as plan B. My advice would be to study hard for the MCATs - maybe even take a kaplan course if it's been awhile since undergrad (for me, I hadn't had physics of general chem in 6+ years), and see how you do. You can do this (3 nights a week plus a few saturdays) while still working full time in the lab. If you rock it, then apply. If you don't, think about retaking some classes. This is just a different opinion - I certainly don't think you'd hurt your chances by retaking classses (unless of course, you did worse the second time around), I'm just not sure I'd do it unless it was absolutely necessary - it would suck to spend a lot of time stuying for Physics and get scooped on a paper in the meantime...I also think it's just as important to make sure the timing is right. If you think you'll be defending in 2 years or less, then you have time to take the MCAT, apply to schools, and finish your doctorate. However, timelines are awfully hard to stick to in grad school. What I'm saying is, how devoted are you to getting your PhD? It was extremely important to me to finish - I wouldn't have matriculated to med school if I couldn't have defended first - and if that's the case, you need to start talking to your PI and getting on the same page. Good luck!