Honestly, it's a complete crapshoot. I had a very poor MCAT score of 496. Ended up getting 4 interviews (2 MD and 2 DO), with 2 acceptances and 2 waitlists. I ended up getting into a good MD school and have been doing quite well (Step 1: 241). Granted, the rest of my application was really solid, but it just goes to show that you never know what a school will tout as their most important qualities. I ended up applying to 28 schools (19 MD and 9 DO) that had a minimum MCAT score lower than mine, or didn't have a minimum at all. This seemed to work out well for me. I would suggest doing a similar approach if there is a glaring weakness, and this way you don't waste time and money on schools that will flat-out say nope. If you get accepted, then you've played it well. If you don't, then work on your weaknesses and come back stronger... It's not as difficult as some people on this forum site tend to make it seem. I have a buddy at my medschool that applied 3 times to our school. He openly admits about his first 2 times that his application was weak and he was a bit immature. He worked on things and is now in the MD/PhD program... Bottom line, don't freak out. Work hard on putting your best foot forward. Continue to persevere if you don't get accepted the first time. AND BY ALL MEANS, don't listen to people on here that just want to poo-poo everyone's chances. There are tons of schools; it only takes one to say yes. Best of luck.