mRNA/protein concept question

[fatwes]

I understand transcription and translation well but what controls how much protein is made or the amount of mRNA transcribed?

Does this have to do with activators and transcriptional regulation? If a certain mRNA is to be made in greater amounts, would the frequency of transcription initiation complex formation be enough to explain that?



Thanks

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[lixxx669]

I understand transcription and translation well but what controls how much protein is made or the amount of mRNA transcribed?

Does this have to do with activators and transcriptional regulation? If a certain mRNA is to be made in greater amounts, would the frequency of transcription initiation complex formation be enough to explain that?



Thanks

The amount of translation depends on how long the mRNA is sticking around (half-life) and how many copies of the mRNA is available. Usually the translation machinaries (initiation complexes, ribosomes, tRNAs, etc) are not the limited factor

 

[JmanDO]

It's also regulated by things like negative feedback loops (think operons) and physiological conditions.

 

[lixxx669]

It's also regulated by things like negative feedback loops (think operons) and physiological conditions.

Well, feedback inhibitioin usually happen in transcription level rather than translation level.