I go to Hopkins, I'm staying here for the IM residency. Our PD ranks the components of an IM application in the following manner:
-Clinical clerkship grades (Medicine > Peds/Neuro > Surgery/OBGYN/etc)
-Medicine sub-I grade
-Other advanced medicine clerkship grades (MICU, CCU, consults, etc)
-Your letters of recommendation, especially sub-I
-Research/PhD/Year off/Leadership/Something that makes you stand out
-Preclinical grades
-Step I score
-AOA? I forgot where this went
(I can't remember if the following go on this list, but I personally think that: where you go for med school matters a little, and whether your school will pick up the phone and make calls for you matters)
Anyway, I can't even remember the order beyond line 4 or 5, but I am sure the Step I factored in low. I was shocked when I heard how low he considered the step I score. But that's how it goes here. As long as you didn't fail your first attempt or get way below mean, you'll be fine. I echo everyone else in saying that a 215-225 won't hurt you since you all have PhDs. That being said, I do believe (my personal belief) that a bad medicine clerkship/sub-I grades and letters will hurt somewhat.