Need to know specific CYP450 inducers/inhibitors?

[yoyoma8]

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Does anyone know if the test stresses which drugs/substances affect for instance CYP3A4 or CYP2C? Or is it enough just to know what's a general Cytochrome P450 inducer/inhibitor? Thanks!

 

[Tig2575]

Does anyone know if the test stresses which drugs/substances affect for instance CYP3A4 or CYP2C? Or is it enough just to know what's a general Cytochrome P450 inducer/inhibitor? Thanks!

Just know the ones that induce / inhibit generally, but also know that Proton Pump Inhibitors (specifically omeprazole) inhibit CYP2C19, which decreases the bioactivation of clopidogrel.

 

[sirius08]

Step 1 questions are little puzzles that are easy if you recognize the clues, but difficult if you don't. Just memorize the list of P450 inducers / inhibitors in FA -- there aren't that many.

 

[jfgavina]

easy:

inducers

BCG PQRS

Barbiturates, Carbamazepine, Griseofulvin, Phenytoin, Quinidine, Rifampin, St Johns wort


inhibitors:

PICK EGS

Protease inhibitors, INH, Cimetidine, Ketoconazol, Erythromycin, Grapefruit juice, Sulfonamides

 

[jfgavina]

Step 1 questions are little puzzles that are easy if you recognize the clues, but difficult if you don't. Just memorize the list of P450 inducers / inhibitors in FA -- there aren't that many.

you just said everything 🙂 FA has the rules of the game

 

[ctizzle13498]

easy:

inducers

BCG PQRS

Barbiturates, Carbamazepine, Griseofulvin, Phenytoin, Quinidine, Rifampin, St Johns wort


inhibitors:

PICK EGS

Protease inhibitors, INH, Cimetidine, Ketoconazol, Erythromycin, Grapefruit juice, Sulfonamides

someone used DIT 😉

 

[jfgavina]

better than first aid mnem!

 

[sirius08]

you just said everything 🙂 FA has the rules of the game

I speak from recent experience. 🙂 The questions are generally not difficult provided that you've memorized the basics. My best advice is to read FA at least 3 times, and do world more than once if you can.