NextStep logic

[The8]

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"Because pyruvate carboxylase is inhibited by increased intracellular NADH levels, the rate of conversion of pyruvate to OAA will decrease"


Is this not wrong. I am pretty sure that OAA levels would increase when NADH levels are high because NADH inhibits the pyruvate dehydrogenase system and therefore gluconeogenesis is encouraged.

 

[wizzed101]

Pyruvate carboxylase is allosterically activated by Acetyl-CoA.

High level NADH can indicate two things in a normal cell: anaerobic state or satiation. The former obviously will not favor gluconeogenesis, and the latter obviously will.

I think they made **** up.

Edit: High NADH may not mean satiation because constant starvation will also lead to increased NADH due to fat/ketone bodies usage. But either way, it will favor gluconeogensis in appropriate organs.

 

[theonlytycrane]

@The8 What was the original question?

 

[Mr. otcoD]

Wouldn't high NADH mean that the cell is saying, "we have enough energy to make ATP. Pyruvate, you shoudl go back to glucose" thus activating pyruvate carboxylase, not inhibit it? hence the conversion of pyruvate to oxaloacetate would increase?
or did i just repeat your problem

 

[The8]

yepp, thats my problem,... NEXTSTEP was definitely wrong.